摘要
目的:调查复旦大学附属妇产科医院(以下简称"我院")碳青霉烯类抗菌药物使用情况,为临床合理用药提供参考。方法:通过我院信息科调取2014—2017年碳青霉烯类抗菌药物的使用信息,并进行回顾性分析,计算和分析碳青霉烯类抗菌药物的销售金额、用药频度(defined daily dose system,DDDs)、抗菌药物使用强度(antibiotics use density,AUD)、药物利用指数(drug utilization index,DUI)及各科室使用情况;并对主要细菌的耐药情况进行分析。结果:2014—2017年,我院碳青霉烯类抗菌药物的销售金额及其占抗菌药物总销售金额的比例呈逐年升高趋势,其销售金额占抗菌药物总销售金额的比例由2014年的2.30%升至2017年的5.38%,其DDDs从495.25升至1 320.00,AUD从0.17 DDDs/(100人·d)升至0.47 DDDs/(100人·d);4年来,注射用亚胺培南西司他丁钠的DDDs排序始终居第1位,其DUI分别为0.79、0.86、0.78及0.84;妇科某病房注射用亚胺培南西司他丁钠的使用量排序居首位;主要检出革兰阴性菌大肠埃希菌和肺炎克雷伯菌对碳青霉烯抗菌药物的耐药率保持稳定。结论:2014—2017年我院碳青霉烯类抗菌药物的销售金额及其占抗菌药物总销售金额的比例、DDDs及AUD逐年升高,其在妇科某病房的使用量排序始终居首位;虽然大肠埃希菌及肺炎克雷伯菌对碳青霉烯类抗菌药物保持高度敏感,但仍需加强对该类抗菌药物临床应用的管控,减少和延缓细菌耐药。
OBJECTIVE： To investigate the application of carbapenem antibiotics in Obstetrics and Gynecology Hospital of Fudan University（hereinafter referred to as ＂our hospital＂）, so as to provide references for clinical rational application of drugs. METHODS： Retrospective analysis was conducted on application data of carbapenem antibiotics during 2014-2017 extracted from department of information in our hospital, the consumption sum, defined daily dose system（DDDs）, antibiotics use density（AUD）, drug utilization index（DUI） and application of various departments of carbapenem antibiotics were calculated and analyzed. And the drug resistance of main bacteria was analyzed. RESULTS： During 2014-2017, the consumption sum of carbapenem antibiotics and its proportion in the total consumption sum of antibiotics increased year by year in our hospital, and its proportion of consumption sum to the total consumption sum of antibiotics increased from 2.30% in 2014 to 5.38% in 2017, its DDDs rose from 495.25 to 1 320.00, and AUD rose from 0.17 DDDs/（100 people ·d） to 0.47 DDDs/（100 people·d）. For four years, the DDDs of imipenem cilastatin sodium for injection ranked the first, with DUI of 0.79, 0.86, 0.78 and 0.84, respectively. The consumption amount of imipenemesitine sodium for injection in the gynecological ward ranked the first. The drug resistance rate of gram-negative bacteria E. coli and klebsiella pneumoniae to carbapenem antibiotics was stable. CONCLUSIONS： During 2014-2017, the consumption sum of carbapenem antibiotics and its proportion of the total consumption sum of antibiotics, DDDs and AUD increased year by year in our hospital, and its application in the gynecological ward always took the lead. Although E. coli and klebsiella pneumoniae are highly sensitive to carbapenem antibiotics, it is still necessary to strengthen the control clinical application of antibiotics, so as to reduce and delay the bacterial resistance.
作者
王先利
高晶
韩天麟
汤静
WANG Xianli;GAO Jing;HAN Tianlin;TANG Jmg(Dept.of Pharmacy,Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200011,China;Dept.of Clinical LaboratotT,Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200011,China;Dept.of hffot~nation,Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200011,China)
出处
《中国医院用药评价与分析》
2018年第10期1388-1390,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
上海市临床药学重点专科建设项目(No.AB83110002017005)
