摘要
目的探讨乌司他丁联合连续肾脏替代疗法（CRRT）治疗老年感染性休克的价值.方法选取2017年1月至2018年3月本院72例老年感染性休克患者,按照随机数字表法分为观察组与对照组各36例.常规治疗基础上,对照组予以CRRT治疗,观察组给予乌司他丁＋CRRT治疗.对比两组治疗前及治疗7d后血清炎性因子[白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）]水平、病情严重程度,统计对比两组病死率.结果治疗前两组血清IL-6、TNF-α水平及APACHEⅡ评分比较差异无统计学意义（P〉0.05）,治疗7d后观察组血清IL-6、TNF-α水平及APACHEⅡ评分低于对照组（P〈0.05）;观察组病死率8.33%（3/36）与对照组16.67%（6/36）比较差异无统计学意义（P〉0.05）.结论乌司他丁联合CRRT治疗老年感染性休克,可有效减轻机体炎症反应,缓解病情严重程度,病死率低.
Objective To investigate the value of ulinastatin combined with continuous renal replacement therapy （CRRT） in the treatment of senile septic shock. Methods Seventy-two elderly patients with septic shock from January 2017 to March 2018 were enrolled and were divided into observation group and control group according to the random number table method, 36 cases in each group. On the basis of conventional treatment, the control group was treated with CRRT, and the observation group was treated with ulinastatin ＋ CRRT. Serum infammatory factors [interleukin-6 （IL-6）, tumor necrosis factor-α （TNF-α）] levels and the severity of disease were compared between the two groups before treatment and 7 days after treatment. The mortality of the two groups were statistically compared. Results There were no statistically significant differences in serum IL-6, TNF-α levels, and APACHE II score between the two groups before treatment （P〉0.05）; after 7 days of treatment,serum IL-6, TNF-α levels, and APACHE II score in the observation group were lower than those in the control group （P〈0.05）. There was no statistically significant difference in the mortality rate between the observation group and the control group [8.33% （3/36） vs. 16.67% （6/36）] （P〉0.05）. Conclusion Ulinastatin combined with CRRT in the treatment of senile septic shock can effectively reduce the body＇s infammatory response, relieve the severity of the disease, with low mortality rate.
作者
兀瑞俭
巩德成
王强
刘晋豫
Wu Ruijian;Gong Decheng;Wang Qiang;Liu Jinyu(Emergency Department,Yellow River Sanmenxia Hospital,Sanmenxia 472000,China)
出处
《国际医药卫生导报》
2018年第21期3302-3304,共3页
International Medicine and Health Guidance News
关键词
感染性休克
连续肾脏替代疗法
乌司他丁
炎性因子
Septic shock
Continuous renal replacement therapy
Ulinastatin
Infammatory factor
