摘要
目的观察参麦注射液对急性缺血性脑卒中住院患者血液凝血指标及下肢深静脉血栓形成的影响,为参麦注射液的临床应用提供参考。方法选择2016年1月—2017年12月收治的106例急性缺血性脑卒中患者,随机分为对照组和观察组,每组各53例,对照组给予常规和对症治疗,观察组在常规治疗基础上加用参麦注射液。治疗前和治疗后1周分别检测2组的纤维蛋白原、红细胞比容、血浆黏度和D-二聚体含量及进行双下肢血管彩色多普勒超声检查,记录可能的药物不良反应,采用SPSS 21. 0统计软件进行统计分析。结果与治疗前相比,对照组和观察组的纤维蛋白原、红细胞比容、血浆黏度和D-二聚体含量均降低(P <0. 05);治疗后,观察组的纤维蛋白原、血浆黏度和D-二聚体含量低于对照组(P <0. 05),观察组的下肢深静脉血栓可疑症状和体征及多普勒检查出现血栓比例低于对照组(P <0. 05),2组均未出现明显的药物不良反应。结论参麦注射液对急性缺血性脑卒中住院患者血液凝血指标有一定改善作用,对下肢深静脉血栓形成有一定预防价值,但本研究只进行了短期效果的评价,且观察指标有限,确切的疗效期待多中心更大规模的深入研究。
Objective To observe the effect of Shenmai injection on blood coagulation index and deep venous thrombosis in patients with acute ischemic stroke, and to provide reference for the clinical application of Shenmai injection. Methods From January, 2016 to December, 2017, 106 patients with acute ischemic stroke were randomly assigned to the control group and observation group, with 53 cases in each group, the control group was given routine and symptomatic treatment, and the observation group added Shenmai injection on the basis of routine treatment, before and one week after treatment, the two groups of human fibrinogen, packed cell volume, plasma viscosity, D-Dimer content and double leg blood vessel color Doppler uhrasonography were examined, and the possible adverse drug reactions were recorded. SPSS 21.0 statistical software was used to carry out statistical analysis. Results The human fibrinogen, packed cell volume, plasma viscosity, D-Dimer content in the control group and the observation group were decreased （ P 〈 0.05 ）. After the treatment, human fibrinogen, plasma viscosity, D-Dimer content in the observation group were decreased as compared with the control group （ P 〈 0.05 ） , the suspected symptoms and signs of deep vein thrombosis of the legs and the proportion of thrombus by the Doppler examination in the observation group were lower than that of the observation group （P 〈 0.05）. There was no obvious adverse drug reaction in the two groups. Conclusion Shenmai injection has a certain improvement on blond coagulation indexes in patients with acute ischemic stroke, and has certain preventive value for the formation of deep venous thrombosis, however, this study only evaluated the short-term effect, and the observation index is limited, and the exact effect expected a more large-scale and in-depth study.
作者
罗小春
陈娟
朱衡亚
龚文健
LUO Xiao-chun;CHEN Juan;ZHU Heng-ya(Department of Neurology,the 98 Hospital of the Chinese People＇s Liberation Army,Huzhou,Zhejiang 313000,China)
出处
《中华全科医学》
2018年第11期1832-1835,共4页
Chinese Journal of General Practice
基金
浙江省医学会临床科研基金项目(2016ZYC-A67)
