摘要
为探索光甘草定(PT)在治疗银屑病方面的作用,通过建立咪喹莫特乳剂(IMQ)诱导的小鼠银屑病耳廓肿胀模型和背部皮肤破损模型,再根据PT在人体皮肤用药标准设置不同含量进行给药。结果表明,在PT含量分别为30和15 g/kg时对小鼠耳廓红肿程度具有明显抑制效果,抑制率高达68. 37%和56. 98%。同时,对小鼠背部皮肤红肿、鳞屑、浸润增厚程度进行银屑病面积和严重程度指数(Psoriasis area severity index,PAIS)评分,绘制趋势线以观察各组小鼠皮损的变化情况,发现PT含量为30 g/kg时对小鼠皮损具有明显的抑制效果。
To explore the role of glabridin in the treatment of psoriasis, the model of auricle swelling and back skin damage induced by imiquimod emulsion （IMQ） in mouse were established, and then different doses of PT were given according to the standard of human skin administration. Results show that the PT contents of 30 and 15 g/kg have significant inhibitory effects on the degree of auricle swelling in mouse, and the inhibitory rate is 68. 37% and 56.98% respectively. In the meantime, the psoriasis area severity index （PALS） was scored on the back skin erythema, scale and thickness of the mouse. The trend line was drawn to observe the changes of skin lesions in each group. At 30 g/kg, PT has significant inhibitory effect on skin lesions of mouse.
作者
洪婷
刘晓英
车飙
唐健
刘光荣
杜志云
HONG Ting;LIU Xiao-ying;CHE Biao;TANG Jian;LIU Guang-rong;DU Zhi-yun(Guangdong University of Technology-,Guangzhou,Guangdong 510006,China;hffinitus（China）Company Ltd.,Guangzhou,Guangdong 510000,China)
出处
《日用化学工业》
CAS
CSCD
北大核心
2018年第11期643-646,共4页
China Surfactant Detergent & Cosmetics
关键词
护肤品
光甘草定
银屑病
活性研究
skin care product
glabridin
psoriasis
activity research
