摘要
目的探讨冠心病合并高脂血症的住院患者餐后低血压(PPH)的临床特点、相关危险因素、住院期间不良事件及短期预后。方法选取2013年12月至2014年12月冠心病合并高脂血症患者124例作为研究对象,依据高血压发生时间分为发生餐后低血压组(PPH组,17例)和未发生餐后低血压组(非PPH组,107例),比较两组的临床特点,研究PPH的相关危险因素、不良事件发生情况,随访24个月的全因死亡、心脑血管等不良事件的远期预后。结果 PPH组和非PPH组在年龄、性别、进餐时体位、合并脑血管病、应用高血压药物方面比较,差异未见统计学意义(P> 0. 05);在合并高血压方面,PPH组较非PPH组高(P <0. 05);在年龄分组上PPH的发生率比较差异未见统计学意义(P> 0. 05); PPH组三餐前平均收缩压高于非PPH组(P <0. 05);患者早餐和晚餐的PPH发生率高于午餐(P <0. 05);基础血压高的患者其PPH发生率高于基础血压低的患者(P <0. 05); Logistic回归分析表明,基础收缩压水平为餐后低血压的危险因素(P <0. 05)。住院期间PPH组和非PPH组患者心脑血管不良事件发生率比较差异未见统计学意义(P> 0. 05);随访24个月PPH组和非PPH组再住院、心脑血管事件、死亡等不良事件比较差异未见统计学意义(P> 0. 05)。结论基础收缩压水平高会增加PPH的发生率,PPH对患者住院期间心脑血管事件和短期预后无明显影响。
Objective To study the clinical characteristics,risk factors,adverse events and shortterm prognosis of postprandial hypotension（ PPH） in hospitalized patients with coronary heart disease and hyperlipidemia. Methods From December 2013 to December 2014,124 patients with coronary heart disease and hyperlipidemia were selected as the research objects,divided into postprandial hypotension group（ PPH group） and without postprandial hypotension group（ non PPH group）,the clinical features were compared and PPH related risk factor were studied,the adverse events were observed and were followed-up two years the long-term prognosis of death,cardiovascular and other adverse events were followed-up. Results There was no significant difference in the incidence of the age, sex, dining position, cerebrovascular disease,antihypertensive agents or hypertension（ P〉0. 05）. There was no significant difference in the incidence of PPH in different age groups. The average of systolic blood pressure before dinner of PPH group was higher than that of non PPH group（ P〈0. 05）. The incidence of patients with PPH for breakfast and dinner meals was higher that for lunch（ P〈0. 05）. The higher the level of the baseline of systolic blood pressure,the higher the incidence of PPH（ P〈0. 05）. Logistic regression analysis showed that the basal systolic blood pressure was the risk factors for PPH. There was no significant difference in the incidence of adverse events between the PPH group and the non PPH group during the hospitalization. There was no significant difference in adverse events such as rehospitalization,cardio cerebral vascular events and death in group PPH and non PPH group for 24 months（ P〉0. 05）. Conclusions The high level of basic systolic pressure could increase the incidence of PPH,and PPH has no significant effect on the cardio-cerebrovascular events in patients＇ hospitalization and short-term prognosis.
作者
张亚楠
陈天磊
耿雪
谷国强
郑红梅
杨晓红
张冀东
谢瑞芹
崔炜
Zhang Ya＇nan;Chen Tianlei;Geng Xue;Gu Guoqiang;Zheng Hongmei;Yang Xiaohong;Zhang Jidong;Xie Ruiqin;Cui Wei(First Department of Cardiology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Six Department of Cardiology,Hebei People＇s Hospital,Shijiazhuang 050000,China)
出处
《临床医学》
CAS
2018年第10期1-4,共4页
Clinical Medicine
基金
河北省医学科研基金(20170570)~~
关键词
餐后低血压
高脂血症
冠心病
预后
Postprandial hypotension
Hyperlipemia
Coronary heart disease
