摘要
目的:研究益肾祛斑消白汤治疗紫癜性肾炎(HSPN)的临床疗效,并探讨益肾祛斑消白汤对HSPN患者TNF-α和VCAM-1水平的影响。方法:纳入本院120例HSNP患者作为研究对象,采用随机数字表法将患者分为研究组和对照组,每组各60例。对照组给予双嘧达莫、维生素C、替米沙坦及糖皮质激素等西医常规治疗。研究组在常规治疗基础上,加用益肾祛斑消白汤。比较两组治疗效果,记录治疗前后患者尿红细胞计数、24h尿蛋白定量、血浆白蛋白、胱抑素C,比较TNF-α和VCAM-1水平。结果:研究组与对照组的总有效率分别为95%和81.67%,两组比较差异有统计学意义(P <0.05)。治疗后研究组尿红细胞计数、24h尿蛋白定量及胱抑素C均显著低于对照组,血浆白蛋白水平显著高于对照组(P<0.05)。治疗后观察组TNF-α和VCAM-1显著低于对照组(P<0.05)。结论:益肾祛斑消白汤治疗HSPN具有良好的临床疗效,可能与其调节TNF-α和VCAM-1水平有关。
Objective： To study the clinical effect of Yishen Quban Xiaobai decoction and the TNF-α and VCAM-1 in patients with henoch schonlein purpura nephritis （HSPN） were analyzed. Methods： 120 patients with HSNP in our hospital were selected as the research subjects and the patients were randomly divided into the study group and the control group,60 cases in each group. The control group received dipyridamole, vitamin C, telmisartan and glucocorticoid, and the study group was given Yishen Quban Xiaobai decoction on the basis of conventional treatment.The therapeutic effects of the two groups were compared. The urinary red blood cell count, 24-hour urinary protein, plasma albumin and cystatin C were recorded before and after treatment. The levels of TNF-alpha and VCAM-1 were compared.Results：The urinary red blood cell count, 24-hour urinary protein and cystatin C in the study group after treatment were significantly lower than those in the control group,the plasma albumin level was significantly higher than that in the control group,the difference were statistically significant （ P 〈0.05）.The TNF-α and VCAM-1 levels in the observation group were significantly lower than those in the control group,the difference was statistically significant（ P 〈0.05）.Conclusion：The Yishen Quban Xiaobai decoction has good clinical efficacy of treatment of HSPN, which may be related to the regulation of TNF-a and VCAM-1 levels.
作者
郭补林
郭亚平
刘旭琴
郑通
马骏
Guo Bulin;Guo Yaping;Liu Xuqin(Yulin City Traditional Chinese Medicine Hospital in Shaanxi Province,Yulin 719000)
出处
《陕西中医》
2018年第12期1709-1711,共3页
Shaanxi Journal of Traditional Chinese Medicine
基金
陕西省榆林市科技计划项目(2060499-43)
关键词
肾炎/中西医结合疗法
@益肾祛斑消白汤
疗效比较研究
Nephritis/integrated Chinese traditional and western medicine therapy
@Yishen Quban Xiaobai decoction
Comparative effectiveness research
