摘要
目的:探讨顺气活血汤联合β-七叶皂苷钠治疗胸部创伤致急性肺损伤疗效及血清铁蛋白、超氧化物歧化酶和肺功能的影响。方法:以胸部创伤致急性肺损伤114例患者作为研究对象,随机将其划分成治疗组和对照组,每组各57例。对照组给予β-七叶皂苷钠治疗,治疗组在对照组基础上配合顺气活血汤治疗。观察对比两组患者血气指标、血清铁蛋白水平、超氧化物歧化酶活性及肺功能指标。结果:两组治疗后SpO_2、PaO_2、PaCO_2/FiO_2水平均较治疗前出现显著升高(P<0.05),PaCO_2水平均较治疗前出现显著下降(P<0.05),且研究组SpO_2、PaO_2、PaCO_2、PaCO_2/FiO_2水平变化程度显著优于对照组(P<0.05)。两组治疗后血清铁蛋白水平均较治疗前出现显著下降(P<0.05),且研究组血清铁蛋白水平降低程度显著优于对照组(P<0.05)。两组治疗后超氧化物歧化酶活性均较治疗前出现显著升高(P<0.05),且研究组超氧化物歧化酶活性升高程度显著优于对照组(P<0.05)。两组治疗后肺功能指标均较治疗前出现显著改善(P<0.05),且研究组肺功能指标显著优于对照组(P<0.05)。结论:胸部创伤致急性肺损伤患者实施顺气活血汤配合β-七叶皂苷钠进行治疗,临床疗效较好,可显著改善患者血气指标,调节血清铁蛋白水平以及超氧化物歧化酶活性,改善肺功能。
Objective： To investigate the effect of Shunqi Huoxue decoction combined with β-Sodium Aescinate in the treatment of acute lung injury caused by thoracic trauma and it influences on serum ferritin, superoxide dismutase and lung function. Methods： 114 cases of patients with acute lung injury caused by thoracic trauma were selected as the research subjects, they were randomly divided into treatment group and control group, with 57 cases in each group. The control group was treated with β-Sodium Aescinate, and the treatment group was treated with Shunqi Huoxue decoction on the basis of the control group. Blood gas index, serum ferritin level, superoxide dismutase activity and lung function index of two groups were observed and compared. Results： After treatment, the levels of SpO 2 , PaO 2 and PaCO 2 /FiO 2 in the two groups were significantly higher than those before treatment （ P 〈 0.05）, the level of PaCO 2 was decreased significantly compared with that before treatment （ P 〈 0.05）, the levels of SpO 2 , PaO 2 , PaCO 2 and PaCO 2 /FiO 2 in the study group were significantly better than those in the control group （ P 〈0.05）. After treatment, the levels of serum ferritin in the two groups were significantly lower than those before treatment （ P 〈0.05）, the level of serum ferritin in the study group was significantly lower than that in the control group （ P 〈0.05）. After treatment, the activities of superoxide dismutase （SOD） in the two groups were significantly higher than those before treatment （ P 〈0.05）, the level of superoxide dismutase activity in the study group was significantly higher than that in the control group （ P 〈0.05）.After treatment, the lung function indexes of the two groups after treatment were significantly improved compared with those before treatment （ P 〈0.05）, the lung function index of the study group was significantly better than that of the control group （ P 〈0.05）. Conclusion： Shunqi Huoxue decoction combined with β-Sodium Aescinate in the treatment of patients with acute lung injury caused by thoracic trauma has a accurate clinical effect, it can significantly improve the blood gas index of patients, regulate serum ferritin level and superoxide dismutase activity, improve the lung function.
作者
张克
路遥
李德冰
梁少杰
Zhang Ke;Lu Yao;Li Debing(Department of Thoracic Surgery,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003)
出处
《陕西中医》
2018年第12期1798-1801,共4页
Shaanxi Journal of Traditional Chinese Medicine
关键词
肺损伤/中西医结合疗法
创伤和损伤
@顺气活血汤
Lung injury/integrated
Chinese traditional and western medicine therapy
Wounds and injuries
@Shunqi Huoxue decoction
