摘要
以二氯甲烷作为聚合物溶剂,利用超临界CO_2诱导相分离-循环干燥过程制备了质量比为1∶1的聚乳酸和聚己内酯混合物组织工程用多孔支架,同时考察了过程操作压力和温度、溶液浓度、CO_2流量及循环干燥时间等操作参数对孔径大小和形态的影响。结果表明,溶液浓度、操作压力和温度及CO_2流量对孔结构的影响较大。溶液浓度增大、操作温度升高均会引起混合物支架孔径的减小。操作压力升高,混合物多孔支架孔径逐渐增大,孔径分布越来越不均匀。随CO_2流量升高,混合物支架的孔径不断减小。循环干燥时间虽然对混合物支架的孔结构影响不大,但对超临界CO_2诱导相分离-循环干燥过程的可实现性有重要的影响。实验范围内,当混合物溶液浓度为25%(质量分数),循环干燥用CO_2流量为31kg/h,操作压力和温度分别为12 MPa和45℃的操作条件下,制备的混合物多孔支架更有利于组织工程的应用。
With dichloromethane as solvent, the poly（lactic acid）/poly（caprolactone） mixture tissue engineering scaffolds with mass ratio of 1：1 were prepared by supercritical CO 2 induced phase separation-circulation drying process. The influences of operating parameters, such as polymer concentration, operating pressure, operating temperature, cycling drying time and CO 2 flow rate, on the pore size and structure are also investigated. The results showed that with the increasing of polymer concentration and operation temperature, the diameters of pore scaffolds decreased. With the increasing of the operating pressure, the diameters of pore scaffolds increased and pore diameter distribution became non-uniform. With the increasing of CO 2 flow rate, the diameters of pore scaffolds decreased. Circulation drying time made a little influence on the scaffolds pore diameters, but had an important influence on process feasibility. In the range of this work, the mixture scaffolds, prepared at the blend solution of 25 wt%, the operating pressure of 12 MPa, the operating temperature of 45 ℃, the CO 2 flow rates of 31 kg/h, are favorable to tissue engineering.
作者
蒋静智
马莉营
崔海亭
彭培英
耿士敏
JIANG Jingzhi;MA Liying;CUI Haiting;PENG Peiying;GENG Shimin(School of Mechanical Engineering,Hebei University of Science and Technology,Shijiazhuang 050018,China)
出处
《功能材料》
EI
CAS
CSCD
北大核心
2018年第11期11188-11193,11199,共7页
Journal of Functional Materials
基金
河北省自然科学基金资助项目(2012208049)
河北省教育厅科学研究重点支持资助项目(ZD2014011)
河北科技大学基金项目
关键词
超临界流体
聚乳酸和聚己内酯
组织工程
多孔支架
supercritical fluid
poly（lactic acid）/poly（caprolactone） mixture
tissue engineering
porous scaffold
