摘要
目的对比分析肝细胞癌患者应用开腹肝癌切除术与腹腔镜肝癌切除术治疗的临床效果。方法对2015年4月~2018年3月期间在我院接受治疗的90例肝细胞癌患者进行研究,依照随机方法分为两组,即对照组(n=45)和观察组(n=45)。对照组患者应用开腹肝癌切除术治疗,观察组患者应用腹腔镜肝癌切除术治疗,统计比较两组患者的手术相关指标、并发症发生率及术前、术后免疫功能情况。结果观察组术中出血量少于对照组,切口长度、绝对卧床时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率(4.4%)低于对照组(17.8%),差异有统计学意义(P<0.05)。观察组术后外周血CD3+、CD4+T细胞水平高于对照组,CD8+T细胞水平低于对照组,差异有统计学意义(P<0.05)。结论在肝细胞癌治疗中,腹腔镜肝癌切除术的创伤更小,术中出血量更少,有助于患者术后恢复,且对患者免疫功能的影响更小,值得临床应用与借鉴。
Objective To compare and analyze the clinical effects of open hepatectomy for liver cancer and laparoscopic liver cancer resection in patients with hepatocellular carcinoma. Methods 90 patients with hepatocellular carcinomawho were treated in our hospital from April 2015 to March 2018 were enrolled in the study. They were divided into twogroups according to the randomized method, including the control group（n=45） and the observation group（n=45）. Patientsin the control group were treated with open liver cancer resection. Patients in the observation group were treated withlaparoscopic liver cancer resection. The surgical related indexes, complication rate and preoperative and postoperativeimmune function were compared between the two groups. Results The intraoperative blood loss in the observation groupwas lower than that in the control group. The length of incision, absolute bed rest, and hospital stay in the observationgroup was shorter than that of the control group, and the difference was statistically significant（P〈0.05）. The incidenceof complications in the observation group（4.4%） was lower than that in the control group（17.8%）, and the differencewas statistically significant（P〈0.05）. The levels of CD3＋and CD4＋T cells in the peripheral blood of the observationgroup were higher than those of the control group after surgery, and the level of CD8＋T cells in the observation groupwas lower than that of the control group（P〈0.05）. Conclusion In the treatment of hepatocellular carcinoma, laparoscopicliver cancer resection has smaller trauma, less intraoperative blood loss, which is helpful for postoperative recovery, and has less impact on the immune function of patients. It is worthy of clinical application and reference.
作者
赵冠安
王理富
徐胜前
管静静
ZHAO Guan＇an;WANG Lifu;XU Shengqian;GUAN Jingjing(Second Department of Emergency,Lishui People＇s Hospital in Zhejiang Province,Lishui 323000,China;Hepatobiliary and Pancreatic Surgery,Lishui People＇s Hospital in Zhejiang Province,Lishui 323000,China;Department ofPharmacy,Lishui People＇s Hospital in Zhejiang Province,Lishui 323000,China)
出处
《中国现代医生》
2018年第29期71-73,78,共4页
China Modern Doctor
基金
浙江省科技计划项目(2014C33146)
关键词
肝细胞癌
开腹肝癌切除术
腹腔镜肝癌切除术
并发症
免疫功能
Hepatocellular carcinoma
Open hepatectomy for liver cancer
Laparoscopic liver cancer resection
Complications
Immune function
