摘要
白介素(IL)-35是新近发现的IL-12家族抑制性细胞因子,在T细胞、B细胞免疫应答及传播性免疫耐受过程中发挥重要调控作用。目前尚未发现IL-35具备促炎效应。新近,炎症及自身免疫性疾病的相关基础及临床研究揭示了IL-35的病理生理学意义及其对疾病发生、发展及转归的重大影响。IL-35有望成为炎症及自身免疫性疾病诊断、监测及判断预后的重要免疫学指标,也是潜在的调控、治疗靶点。对IL-35表达及调控的深入研究,将为临床诊治炎症及自身免疫性疾病提供崭新的思路及方向。
Interleukin-35 （IL-35） is a newly identi？ed inhibitory cytokine of IL-12 family. In a variety of immune responses mediated by T and B cells, IL-35 has been proved to play a vital role of immunological regulation. IL-35 further contributes to the propagation of immune tolerance, which is crucial for maintenance of immune balance and restriction of inflammatory injuries. Heretofore, no pro-inflammatory effects of IL-35 have been discovered. Recent basic and clinical studies on inflammatory and autoimmune diseases have revealed the pathophysiological significance of IL-35 and its significant impact on the occurrence, development and prognosis of diseases. IL-35 is expected to become an important immunological marker for the diagnosis, monitoring and prognosis of in？ammatory and autoimmune diseases, as well as a potential target for regulation and treatment. The in-depth study of IL-35 expression and regulation will provide new ideas and directions for clinical diagnosis and treatment of in？ammatory and autoimmune diseases.
作者
吴田田
童亚林
姚咏明
Wu Tiantian;Tong Yalin;Yao Yongming(Trauma Research Center,First Hospital Affliated to the Chinese PLA General Hospital,Beijing 100048,China;Hepatobiliary Surgery Department of Peking University International Hospital,Beijing 102206,China;Department of Burn and Plastic Surgery,181st Hospital of Chinese PLA,Guilin 541002,China)
出处
《中华重症医学电子杂志》
2018年第4期314-319,共6页
Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)
基金
国家自然科学基金重点项目(81730057
81372054
81772120)
国家重点研发计划项目(2017YFC1103302)
漓江学者计划资助项目
关键词
白介素-35
炎症性疾病
自身免疫性疾病
免疫学效应
诊断
监测
Interleukin-35
Inflammatory disease
Autoimmune disease
Immunological effect
Diagnosis
Surveillance
