摘要
目的:观察甘精胰岛素联合阿卡波糖治疗老年Ⅱ型糖尿病患者的效果。方法:选取老年Ⅱ型糖尿病患者143例作为观察对象,采用随机数字表法将其分为对照组68例和研究组75例。对照组给予阿卡波糖片治疗,研究组在对照组基础上给予甘精胰岛素治疗。比较两组治疗前后的FBG、2 h PG、HbA1c等血糖指标和胰岛素分泌指数(HOMA-B)、胰岛素抵抗指数(HOMA-IR)、餐后C肽(FCP)、空腹C肽(PCP)等胰岛素功能指标及治疗前后的BMI和低血糖发生率。结果:治疗后研究组FBG、2 h PG和HbA1c等血糖指标水平明显低于对照组,HOMA-B、HOMA-IR、FCP和PCP等胰岛素功能指标水平明显优于对照组,差异均有统计学意义(P<0.05);两组治疗前后的BMI比较,差异无统计学意义(P>0.05);对照组低血糖发生率为11.76%,研究组低血糖发生率为16.00%,两组差异无统计学意义(P>0.05)。结论:阿卡波糖联合甘精胰岛素治疗老年Ⅱ型糖尿病患者的效果优于单用阿卡波糖治疗效果。
Objective： To observe effects of insulin glargine combined with Acarbose in treatment of elderly patients with type 2 diabetes mellitus. Methods： 143 elderly patients with type 2 diabetes mellitus were selected as the observation objects. They were divided into control group （68 cases） and study group （75 cases） by using the random number table method. The control group was treated with Acarbose tablets, while the study group was given insulin glargine on the basis of that of the control group. The levels of FBG, 2hPG, and HbA1c, insulin secretion index （HOMA-B）, insulin resistance index （HOMA-IR）, postprandial C-peptide （FCP）, fasting C-peptide （PCP）, BMI and incidence of hypoglycemia before and after the treatment were compared between the two groups. Results： After the treatment, the levels of FBG, 2 h PG and HbA1c in the study group were signifcantly lower than those in the control group; the levels of HOMA-B, HOMA-IR, FCP and PCP were signifcantly better than those of the control group, and the differences were statistically signifcant （P〈0.05）. There were no signifcant differences in BMI between the two groups before and after the treatment （P〉0.05）. Further, the incidences of hypoglycemia in the control group and the study group were 11.76% and 16.00%, respectively, and there was no signifcant difference between the two groups （P〉0.05）. Conclusions： Insulin glargine combined with Acarbose in the treatment of the elderly patients with type 2 diabetes mellitus is superior to single Acarbose.
作者
赵丹
ZHAO Dan(Panjin Central Hospital,Panjin Liaoning 124010,China)
出处
《中国民康医学》
2018年第22期3-4,7,共3页
Medical Journal of Chinese People’s Health
