摘要
目的探讨关节腔内注射倍他米松联合玻璃酸钠治疗老年膝关节炎的临床疗效及对患者生活质量的影响。方法选取2016年4月至2017年5月在我院接受治疗的老年膝关节炎患者76例,按不同用药方法将其分为联合组和对照组,每组38例。对照组患者单独注射玻璃酸钠注射液,联合组患者注射复方倍他米松和玻璃酸钠。比较两组患者的临床疗效、治疗前、后疼痛评分、生活质量综合评定问卷(GQOLI-74)总评分及膝关节周径。结果联合组患者的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者VAS评分均降低,且联合组低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者GQOLI-74总评分均升高,且联合组高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的膝关节周径均减小,且联合组小于对照组,差异具有统计学意义(P<0.05)。结论关节腔内注射倍他米松和玻璃酸钠治疗老年膝关节炎效果显著,能明显改善患者的生活质量,减少疼痛,促进患者病情的恢复。
Objective To investigate the clinical effect of intra -articular injection of betamethasone and sodiumhyaluronate in the treatment of senile knee arthritis and the influence on quality of life. Methods A total of 76 elderlypatients with knee arthritis treated in our hospital from April 2016 to May 2017 were selected and divided into combinationgroup and control group according to different medication methods, with 38 cases in each group. The control group wasinjected with sodium hyaluronate injection alone, and the combination group was injected with compound betamethasone andsodium hyaluronate. The clinical efficacy, pain scores, total GQOLI -74 scores and knee circumference were comparedbetween the two groups. Results The total effective rate of treatment in the combination group was higher than that in thecontrol group, and the difference was statistically significant （P〈0.05）. After treatment, the VAS scores of the two groupsdecreased, and that of the combination group was lower than the control group, and the differences were statisticallysignificant （P〈0.05）. After treatment, the total scores of GQOLI-74 in the two groups increased, and that of the combinationgroup was higher than the control group, and the differences were statistically significant （P〈0.05）. After treatment, the kneecircumference of the two groups decreased, and that of the combination group was smaller than the control group, and thedifferences were statistically significant （P〈0.05）. Conclusion The intra-articular injection of betamethasone and sodiumhyaluronate in the treatment of senile knee arthritis has a remarkable effect, which can obviously improve patients＇ quality oflife, reduce pain and promote the recovery of patients＇ condition.
作者
孙晓辉
闫宏林
任浩
李文军
SUN Xiao-hui;YAN Hong-lin;REN Hao;LI Wen-jun(Xi＇an Fengcheng Hospital,Xi＇an 710016,China)
出处
《临床医学研究与实践》
2018年第33期74-75,146,共3页
Clinical Research and Practice
关键词
老年膝关节炎
玻璃酸钠
倍他米松
关节腔内注射
senile knee arthritis
sodium hyaluronate
betamethasone
intra-articular injection
