摘要
脂蛋白（a）[Lp（a）]是动脉粥样硬化（As）形成与进展的高危因素，血浆中高浓度的Lp（a）已成为公认的冠心病预测因子。研究表明，与Lp（a）相连的氧化磷脂（OxPL）成分可能是其致AS的关键因素，而与Lp（a）相连的另一个组分——脂蛋白相关磷脂酶A2（LV—PLA2）可水解OxPL，其水解产物溶血磷脂酰胆碱（Lyso．PC）和游离氧化脂肪酸（oxFFA）是促进AS发生发展的重要炎症因子。脂蛋白相关磷脂酶A2水解脂蛋向（a）连接的氧化磷脂可产生炎性因子，促进动脉粥样硬化的发生发展。OxPL和Lp—PLA2可作为心血管疾病（CVD）新靶标，具有潜在预测指标的临床应用价值。
Lipoprotein （ a ） [ Lp （ a ） ] is considered a causal risk factor for the formation and development of atherosclerosis （AS）. High plasma levels of Lp （a） is recognized as a predictor of coronary heart disease. However, the pathogenic mechanisms of Lp （a） are still unknown. Recent studies demonstrated that a key role in the proatherogenic effects of Lp （ a ） may be linked to its oxidized phospholipids （OxPL） content. Lipoprotein-associated phospholipase A2 （Lp-PLA2） is another important factor in Lp（a） functionality. OxPL are hydrolyzed by Lp-PLA2 into lysophosphatidylcholine （lyso-PC） and oxidized free fatty acid （OxFFA） , which are important inflammatory factors on promoting the occurrence and development of AS. The present review article describes Lp-PLA2 hydrolyzing OxPL associated with Lp（a）. The process induces inflammatory factors, which promote development of AS. OxPL and Lp-PLA2 can be used as new targets of cardiovascular diseases, which have clinical application value to predict potential cardiovascular diseases . （
作者
刘航齐
贾玫
Liu Hangqi;Jia Mei(Department of Clinical Laboratories,Peking University People＇s Hospital,Beifing 100044,China)
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2018年第11期897-900,共4页
Chinese Journal of Laboratory Medicine
