摘要
目的探讨血浆同型半胱氨酸(Hcy)水平与先兆流产、复发性流产及继发性不孕的关系。方法选取2017年1月～2018年4月就诊于江苏省人民医院的194例先兆流产患者为先兆流产组,364例不明原因复发性流产患者为复发性流产组,547例继发性不孕患者为继发性不孕组,500名同期正常进行产前检查的健康孕妇为正常妊娠组,500名同期进行孕前检查的健康孕前女性为正常非妊娠组。比较分析各组Hcy水平、高同型半胱氨酸血症(Hhcy)百分率差异及Hcy水平与先兆流产、复发性流产及继发性不孕的关系。结果与正常非妊娠组比较,正常妊娠组血浆Hcy水平及Hhcy百分率均明显降低,复发性流产组、继发性不孕组均明显升高,差异有高度统计学意义(P <0.01);先兆流产组血浆Hcy水平及Hhcy百分率均有升高趋势,但两组间比较差异无统计学意义(P>0.05)。与正常妊娠组比较,先兆流产组、复发性流产组、继发性不孕组血浆Hcy水平及Hhcy百分率均明显升高,差异有高度统计学意义(P <0.01)。高Hcy水平为先兆流产(OR=1.994)、复发性流产(OR=4.095)、继发性不孕(OR=3.006)的危险因素。结论血浆Hcy水平与先兆流产、复发性流产及继发性不孕相关,Hcy水平升高可能是其发生的一个重要危险因素,在临床诊断和治疗中应多加重视。
Objective To investigate the relationship between homocysteine （Hcy） and threatened abortion, recurrent spontaneous abortion, secondary sterility. Methods From January 2017 to April 2018, in the First Affiliated Hospital of Nanjing Medical University, 194 cases of threatened abortion were selected as threatened abortion group, 364 cases of recurrent spontaneous abortion were selected as recurrent spontaneous abortion group, 547 cases of secondary sterility were selected as secondary sterility group, 500 cases of pregnant women were selected as normal pregnant group and 500 cases of pre-pregnancy women were selected as normal non-gestational group. The level of plasma Hcy, the percentage of Hhcy of each group and the relationship between Hcy and threatened abortion, recurrent spontaneous abortion, secondary sterility were compared and analyzed. Results Compared with the normal non-gestational group, the plasma Hcy level, percentage of Hhcy were significantly lower in the normal pregnant women group, while significantly higher in the recurrent spontaneous abortion group and the secondary sterility group, the differences were statistically significant （P 〈 0.01）, and those in the threatened abortion group were tend to increase, but without statistically significant difference （P 〉 0.05）. Compared with the normal pregnant group, the plasma Hcy level and the percentage of Hhcy were significantly higher in the threatened abortion group, recurrent spontaneous abortion group and the secondary sterility group, the differences were statistically significant （P 〈 0.01）. The high Hcy level was the risk factor of threatened abortion （OR = 1.994）, recurrent spontaneous abortion （OR = 4.095） and secondary sterility （OR = 3.006）. Conclusion The plasma Hcy level has relationship with the threatened abortion, recurrent spontaneous abortion and secondary sterility, and the increase of plasma Hcy level could be an important risk factor of these diseases, more attention should be paid for clinical diagnosis and treatment.
作者
李孟兰
林宁
石慧
封婕
吴玉璘
崔婷
LI Menglan;LIN Ning;SHI Hui;FENG Jie;WU Yulin;CUI Ting(Jiangsu Institute of Planned Parenthood Research,Jiangsu Clinical Laboratory of Reproductive Health,Jiangsu Province,Nanjing,210036,China;Department of Clinical Laboratory,the First Affiliated Hospital of Nanjing Medical University,Jiangsu Province,Nanjing,210029,China)
出处
《中国医药导报》
CAS
2018年第33期64-67,共4页
China Medical Herald
基金
江苏省科技基础设施建设计划项目(BM2015020-2)
江苏省卫计委科研项目(Z201507)
关键词
同型半胱氨酸
先兆流产
复发性流产
继发性不孕
Homocysteine
Threatened abortion
Recurrent spontaneous abortion
Secondary sterility
