摘要
目的建立广州花都地区妊娠妇女血清甲状腺指标的参考区间,为临床诊断、监测孕妇的甲状腺疾病提供参考。方法收集2017年6月—2018年4月在广州市中西医结合医院产检的孕妇3 326名,采用序贯抽样检验方案的方法筛选上述人群中符合美国临床生化研究院(NACB)推荐标准的孕妇1 154名,同时收集检测131名同期健康非妊娠妇女的甲状腺指标作为参考,建立各孕期甲状腺指标的参考区间;甲状腺指标测定采用ROCHE电化学发光免疫方法;参考值范围采用中位数(P50)及双侧限值(P2. 5,P97. 5)表示。结果本地区孕妇在不同孕期的甲状腺指标的参考区间,中位数(P50)分别为孕早期TSH 1. 41μIU/mL、FT3 4. 81 pmol/L、FT4 16. 01 pmol/L,孕中期TSH1. 75μIU/mL、FT3 4. 62 pmol/L、FT4 13. 28 pmol/L,孕晚期TSH 1. 93μIU/mL、FT3 4. 31 pmol/L、FT4 11. 16 pmol/L;双侧限值(P2. 5,P97. 5)参考范围为孕早期TSH 0. 03～4. 21μIU/mL、FT3 3. 69～6. 83 pmol/L、FT4 11. 35～23. 09 pmol/L,孕中期TSH 0. 52～4. 87μIU/mL、FT3 3. 39～6. 38 pmol/L、FT4 10. 34～20. 42 pmol/L,孕晚期TSH 0. 72～5. 19μIU/mL、FT3 3. 14～5. 13 pmol/L、FT4 9. 66～16. 94 pmol/L。结论孕妇在孕期的甲状腺激素水平不同于同期非妊娠妇女,孕早、中、晚期之间也存在明显差异,因此建立本地区正常孕妇早、中、晚孕期甲状腺指标的参考区间具有临床意义。
Objective To establish a reference range for serum thyroid index of pregnant women in Huadu district of Guangzhou, and provide reference for clinical diagnose and monitor thyroid disease of pregnant women. Methods A total of 3,326 pregnant women were recruited from June 2017 to April 2018 in Guangzhou Hospital of Integrated Traditional and West Medicine. Sequential sampling test plan was used to screen out 1,154 pregnant women who met the recommendations of the National Institutes of Clinical Chemistry （NACB）. At the same time, the thyroid index of 131 healthy non-pregnant women was collected and used as a reference to establish a reference interval for thyroid index during pregnancy. ROCHE detection system was used to test the thyroid index, with the reference range indicated by median （ P 50 ） and double side limits （ P 2.5 , and P 97.5 ）. Results The median （ P 50 ） of the thyroid index in the pregnant women in different regions was TSH 1.41 μIU/mL, FT3 4.81 pmol/L, FT4 16.01 pmol/L in the early trimester, and TSH 1.75 μIU/mL FT3 4.62 pmol/L, FT4 13.28 pmol/L in the second trimester and TSH 1.93 μIU/mL, FT3 4.31 pmol/L, FT4 11.16 pmol/ in the third trimester. The reference range for bilateral limit （ P 2.5 , P 97.5 ） wa TSH 0.03～4.21 μIU/mL, FT3 3.69～6.83 pmol/L, FT4 11.35～ 23.09 pmol/L in the early trimester, TSH 0.52～4.87 μIU/mL, FT3 3.39～6.38 pmol/L and FT4 10.34～20.42 pmol/Lin the second trimester, and TSH 0.72 to 5.19 μIU/mL, FT3 3.14 to 5.13 pmol/L, and FT4 9.66 to 16.94 pmol/L in the third trimester. Conclusion The pregnant women’s thyroid hormone levels are different from those non-pregnant women in pregnancy. And there are also significant differences between the stages of early, middle and late pregnancy. Therefore, to establish the reference intervals for thyroid indicators in Huadu region of Guangzhou for the early, middle and late pregnancy in normal pregnant women has clinical significance.
作者
丘雪峰
胡汉斌
韩俊
曾小花
罗雪平
QIU Xuefeng;HU Hanbin;HAN Jun;ZENG Xiaohua;LUO Xueping(Guangzhou Hospital of Integrated Traditional and Western Medicines,Guangzhou 510800,China)
出处
《现代医院》
2018年第11期1610-1612,共3页
Modern Hospitals
基金
:广州市花都区科技计划项目(16-HDWS-041)
关键词
妊娠期
甲状腺指标
参考区间
Pregnancy
Thyroid Index
Reference Interval
