摘要
目的探究双歧三联活菌胶囊辅助常规治疗溃疡性结肠炎的临床疗效及对患者T淋巴细胞群、白细胞介素-10的影响。方法选取我院2016年1月～2018年1月收治的溃疡性结肠炎患者共198例,按照随机数字表法分为对照组与观察组,对照组患者接受UC常规治疗,观察组在对照组基础上给与双歧三联活菌胶囊治疗。比较两组患者UC治疗效果、治疗前后T淋巴细胞群CD4^+/CD25^+、CD4^+/CD25^+占T淋巴细胞比例及IL-10水平。结果观察组治疗总有效率为84.00%,显著高于对照组治疗总有效率74.49%,差异有统计学意义(P <0.05)。治疗后观察组结肠炎症积分显著低于对照组,差异有统计学意义(P <0.05)。治疗后,观察组CD4/CD25水平显著高于对照组,CD4、CD25占CD4 T细胞比例显著大于对照组,IL-10水平高于对照组,差异有统计学意义(P <0.05)。结论双歧三联活菌胶囊辅助运用于溃疡性结肠炎的治疗中,能有效提高治疗效果,降低结肠炎症积分,改善患者免疫功能,值得临床运用。
Objective To explore clinical curative effect of bifid-triple viable capsule assisting routine therapy in treatment of ulcerative colitis. Methods 198 patients with ulcerative colitis who were admitted and treated in our hospital from January 2016 to January 2018 were selected and they were divided into the control group and the observation group according to random number table method.Patients in the control group were given UC routine therapy while the observation group was given bifid-triple viable capsule at basis of the eontrol group.Curative effect of UC,the proportion of T lymphoeytepopulations CD4＋/CD25＋ and CD4＋/CD25＋ in T lymphoeytes before and after treatment,and IL-10 level of patients in two groups were compared. Results Total effeetive rate of treatment in the observation group was 84.00%,significantly higher than that of the control group 74.49%,（ P 〈 0.05）.After treatment,score of ulcerative colitis in the observation group was significantly lower than that of the control group （ P 〈 0.05）.After treatment,CD4/CD25 level of the observation group was significantly higher than that of the control group.Proportions of CD4 and CD25 in CD4 T cell of the observation group were significantly higher than those of the control group and IL-10 levelwas higher than the control group（P 〈 0.05）. Conclusion Bifid-triple viable capsule in adjuvanttreatment of ulcerative colitis can effectively improve curative effect,reduce score of ulcerative colitis and improve immune function of patients, which is worthy of clinical application.
作者
田进
王晓凤
TIAN Jin;WANG Xiaofeng(Pingshan District People＇s Hospital,Shenzhen 518118,China)
出处
《中国医药科学》
2018年第20期40-43,共4页
China Medicine And Pharmacy
