摘要
目的探讨两种灌肠方法结合对缓解肝硬化患者肝性脑病症状的效果。方法选取2014年10月～2018年4月在我院进行治疗的130例肝硬化伴肝性脑病患者,将其随机分为常规组及研究组,对常规组患者行常规治疗,并采用白醋及生理盐水进行保留灌肠,对研究组患者进行保留灌肠前,先使用生理盐水对患者进行清洁灌肠,比较两组患者治疗效果,清醒时间、血氨及相应肝功能等指标。结果研究组治疗总有效率为90.77%,常规组为69.23%,差异有统计学意义(P <0.05),且研究组患者治疗后清醒时间及肠内pH值均显著优于常规组,差异有统计学意义(P <0.05),且治疗后,患者BA水平由治疗前的(135.26±13.14)μmol/L降低至(74.14±12.35)μmol/L,与治疗前及常规组比较差异有统计学意义(P <0.05),另外,经治疗后,患者ALT、AST、TBil、IL-6及PCT等指标分别降低至(45.62±4.11)u/L、(48.32±8.52)u/L、(35.18±5.41)μmol/L、(37.52±4.59)pg/mL及(5.41±3.25)pg/mL,与治疗前及常规组均显著差异,差异有统计学意义(P <0.05)。结论对于肝硬化伴有肝性脑病患者,与使用白醋及生理盐水进行保留灌肠前,先使用生理盐水进行清洁灌肠,能够进一步降低患者体内血氨的浓度,对改善患者相应临床症状及提高患者生活质量等方面具有重要意义。
Objective To explore the effeet of two eombined enema methods on relieving hepatie eneephalopathy in patients with liver cirrhosis. Methods 130 patients with liver cirrhosis accompanied by hepatic eneephalopathy who were treated in our hospital from October 2014 to April 2018 were selected and they were randomly divided into the eonventional group and the study group. The eonventional group was given routine treatment with white vinegar and saline for retention enema. Patients in the study group were given eleansing enema with saline before retention enema. Curative effeets, awake time, blood ammonia, and liver funetion of two groups were eompared. Results The total effeetive rate of treatment in the study group and the eonventional group was respeetively 90.77% and 69.23%. The difference was statistically significant （P 〈 0.05）. Awake time and intestinal pH value after treatment of patients in the study group were both signifieantly better than those in the eonventional group and the differenee was statistieally signifieant （P 〈 0.05）. After treatment, the patient＇s BA level deereased from （135.26 ± 13.14） μ moll L before treatment to （74.14 ± 12.35） μmol/L, which was significantly different from that before treatment and in the conventional group. Differences were statistically significant （P 〈 0.05）. After treatment, ALT, AST, TBiI, IL-6 and PCT were respeetively deereased to （45.62 ± 4.11）u/L, （48.32 ± 8.52）u/L, （35.18 ± 5.41） μmol/L, （37.52± 4.59） pg/mL and （5.41 ± 3.25） pg/mL, which were significantly different from those indexes before treatment and in the conventional group. Differences were statistically significant （P 〈 0.05）. Conclusion For patients with liver cirrhosis accompanied by hepatic eneephalopathy, cleansing enema with saline before retention enema with white vinegar and saline can further reduce the concentration of blood ammonia in patients, which is of great significance in improving the eorresponding elinieal symptoms and quality of life of patients.
作者
王蕾
周丽
刘琴
朱建妹
WANG Lei;ZHOU Li;LIU Qin;ZHU Jianmei(Department of Hepatology,Longgang District Hospital of Traditional Chinese Medicine,Shenzhen 518172,China)
出处
《中国医药科学》
2018年第20期160-163,共4页
China Medicine And Pharmacy
关键词
肝性脑病
清洁灌肠
保留灌肠
护理干预
Hepatic eneephalopathy
Cleansing enema
Retention enema
Nursing intervention
