摘要
目的:总结前列腺小细胞神经内分泌癌的临床表现、诊断、治疗及预后,提高对其认识。方法:报告1例42岁中年男性前列腺小细胞神经内分泌癌患者,以下尿路梗阻为表现起病,肛门指检提示前列腺体积左侧增大,前列腺特异性抗原(prostate specific antigen,PSA)正常。泌尿系彩超、CT及MR提示前列腺占位。结果:前列腺穿刺活检组织病理结果显示前列腺小细胞神经内分泌癌。患者行经腹膜外途径腹腔镜下前列腺癌根治术,术后肿瘤复发并转移,采用依托泊苷联合顺铂方案化疗6个疗程,结果使肿瘤体积缩小,效果良好。结论:前列腺小细胞神经内分泌癌为临床罕见病,起病隐匿,症状不典型,以病理检查和免疫组化确诊,早期可行根治性手术治疗,术后或晚期以化疗为主,疗效肯定,生存期短,预后不良。
Objective：To sumnlarize the clinical manifestations, diagnosis, treatment and prognosis of small cell neuroendocrine carcinoma of prostate to better understand the disease. Methods： A 42-year-old patient with small cell neuroendocrine carcinoma of prostate began his disease with symptonls of low urinary tract obstruction. Digital rectal examination showed the left side of the prostate enlarged and prostate specific antigen normal. Urinary ultrasound test, CT and MR showed prostatic cancer. Results： The pathological results of prostate biopsy showed small cell neuroendocrine carcinoma of prostate. The patient was treated by extraperitoneal laparoscopic radical prostatectomy. Results of CT reexanfination found tumor recurrence and distant metastasis. Six courses of etoposide with cisplatin were given, which showed a better cancer cell killing effect. Conclusions： Small cell neuroendocrine carcinoma of prostate is arare disease with concealed onset and atypical symptoms. The diagnosis is based on immunohistochemical and pathological examination. Radical surgery is recommended in the early period of disease and chemotherapy cheers a better effect in the advanced stage or postoperation with short lifetime and poor prognosis.
作者
曾维勇
丘勇超
陈铭
姚睿智
肖扬
ZENG Weiyong;QIU Yongchao;CHEN Ming;YAO Ruizhi;XIAO Yang(The First School of Clinic Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong,China;Department of Urology,The First Hospital Af filiated to Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong,China)
出处
《中国性科学》
2018年第9期5-7,共3页
Chinese Journal of Human Sexuality
基金
广东省省级科技计划项目(10400216)
关键词
前列腺
神经内分泌癌
小细胞
病例报道
Prostate
Neuroendocrine carcinoma
Small cell
Case report
