摘要
目的:对NB-UVB照射联合羌月乳膏治疗生殖器(下体)周边慢性湿疹进行临床研究,观察其疗效和安全性。方法:选择2014年10月至2016年12月荆州市皮肤病防治院收治的生殖器(下体)周边慢性湿疹患者80例,按照随机数字表法将其分为对照组(n=40)和观察组(n=40),对照组患者给予羌月乳膏,观察组患者在对照组治疗基础上给予NB-UVB照射,治疗时间为4周,比较两组患者治疗效果,治疗前后皮损面积、皮损形态、瘙痒程度、疼痛视觉模拟评分表(VAS),Th1型细胞因子[白细胞介素-2(IL-2)]和Th2型细胞因子[白细胞介素-4(IL-4)、白细胞介素-5(IL-5)]水平,湿疹愈合时间,复发情况及不良反应。结果:观察组患者总有效率(87. 5%)显著高于对照组患者(65. 0%),其差异具有统计学意义(P <0. 05)。两组患者治疗前皮损面积、皮损形态、瘙痒程度和VAS评分比较,其差异均无统计学意义(均P> 0. 05);治疗后观察组患者皮损面积、皮损形态、瘙痒程度和VAS评分下降幅度均显著大于对照组患者,其差异均有统计学意义(均P <0. 05)。两组患者治疗前IL-2、IL-4、IL-5水平比较,其差异均无统计学意义(均P> 0. 05);治疗后观察组患者IL-2水平升高幅度和IL-4、IL-5水平降低幅度均显著大于对照组患者,其差异均有统计学意义(均P <0. 05)。观察组患者愈合时间显著少于对照组患者,其差异均有统计学意义(P <0. 05)。观察组患者湿疹复发率(5. 0%)显著低于对照组患者(27. 5%),其差异均有统计学意义(P <0. 05)。观察组患者不良反应发生率(7. 5%)与对照组患者(5. 0%)相比,其差异无统计学意义(P> 0. 05)。结论:NB-UVB照射联合羌月乳膏治疗生殖器(下体)周边慢性湿疹疗效显著,不良反应少。
Objective： To study the efficacy and safety- of NB-UVB irradiation combined with Qiangyue Cream in the treatment of chronic eczema around genitals （private parts）. Methods： A total of 80 patients with chronic eczema around genitals （private parts） treated in ]ingzhou Dermatological Disease Prevention and Treatment Hospital from October 2014 to December 2016 were selected and divided into control group （n = 40） and observation group （n =40） by random number table method. The control group was treated with Qiangyue Cream, and the observation group was treated with Qiangy-ue Crearn combined with NB-UVB irradiation. All patients received 8 weeks of treatment. The therapeutic effects, areas of skin lesions before and after treatment, shape of skin lesions, degree of itching, scores of pain visual analogue scale （VAS）, levels of Thl type eytokines [ interleukin-2 （IL-2） ] and Th2 type eytokines [interleukin-4 （IL-4）, interleukin -5 （IL-5） ], the healing time of eczema, recurrence and adverse reactions were compared between the two groups. Results ： The total effective rate of treatment in the observation group was significantly higher than that in the control group （87.5 % vs 65.0% ） （ P 〈 0.05）. There was no significant difference in areas of skin lesions, shape of skin lesions, degree of itching and VAS score between the two groups before treatment （ all P 〉 0.05 ） , while changes in above-mentioned indexes in the observation group were greater than those in the control group after treatment （ all P 〈 0.05 ）. There was no significant difference in levels of IL-2, IL-4 and IL-5 between the two groups before treatment （ all P 〉 0.05）. After treatment, the increase of IL-2 level and the decrease of IL-4 and IL-5 levels in the observation group was significantly greater than that in the control group （ all P 〈 0.05 ）, and the healing time of the observation group was significantly shorter than that of the control group （ P 〈 0.05 ）. The recurrence rate of eczema in the observation group was significantly lower than that in the control group （5.0% vs 27.5% ） （P 〈 0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （7.5% vs 5.0% ） （P 〉0.05）. Conclusions： NB-UVB irradiation combined with Qiangyue Cream is effective in the treatment of chronic eczema around genitals （private parts） , with few adverse reactions.
作者
裴宇
董洁
万军
孙云
PEI Yu;DONG Jie;WAN Jun;SUN Yun(Department of Dermatology,Jingzhou Dermatological Disease Prevention and Treatment Hospital,Jingzhou 434020,Hubei,China;Department of Cosmetic Dermatology,Jingzhou Central Hospital,Jingzhou 434020,Hubei,China;Department of Traditional Chinese Medicine Dermatology,Jingzhou Dermatological Disease Prevention and Treatment Hospital,Jingzhou 434020,Hubei,China)
出处
《中国性科学》
2018年第9期119-122,共4页
Chinese Journal of Human Sexuality
