摘要
目的对埃索美拉唑钠针剂联合生长抑素治疗非静脉曲张性上消化道出血的有效性评价进行分析。方法选取2015年3月-2018年3月期间收治的132例非静脉曲张上消化道出血患者,随机分为对照组(n=66)与观察组(n=66),对照组采用埃索美拉唑钠针剂治疗,观察组应用埃索美拉唑钠针剂联合生长抑素治疗,对两组患者止血时间、输血量,治疗效果、住院时间、不良反应进行比较。结果观察组止血时间(23.32±4.87)小时,输血量(2.49±0.47)单位,明显低于对照组观察止血时间(27.89±5.22)小时,输血量(3.21±0.66)单位,差异有统计学意义(P<0.05)。观察组治疗效果有效率98.48%,高于对照组的89.39%;观察组住院时间(9.65±0.46)天,低于对照组的(11.41±0.27)天;观察组不良反应发生率7.58%,低于对照组22.73%,差异均有统计学意义(P<0.05)。结论埃索美拉唑钠针剂联合生长抑素治疗上消化道出血具有较好的临床疗效,止血成功率较高,且具有较好临床应用安全性,为临床治疗非静脉曲张性上消化道出血提供依据。
Objective To evaluate the efficacy of esomeprazole sodium injection combined with somatostatin in the treatment of non-varicose upper gastrointestinal hemorrhage. Methods 132 patients with non-varicose upper gastrointestinal bleeding from March 2015 to March 2018 were randomly divided into two groups： control group（n=66）and observation group（n=66）. The control group was treated with esomeprazole sodium injection. The observation group was treated with esomeprazole sodium injection combined with somatostatin. The hemostasis time, blood transfusion volume, therapeutic effect, hospitalization time and adverse reaction were compared between the two groups. Results The hemostasis time was 23.32 in the observation group. The blood transfusion volume（2.49±0.47）unit was significantly lower than that in the control group（27.89±5.22）hours, and the blood transfusion volume was（3.21±0.66）units in the control group（P〈0.05）. The effective rate of treatment in the observation group was 98.48% higher than that in the control group 89.39%,and the hospitalization time in the observation group was（9.65± 0.46）days lower than that in the control group（11.41±0.27）days. The incidence of adverse reactions in the observation group was 7.58% lower than that in the control group（22.73 g）（P〈0.05）. Conclusions Esomeprazole sodium injection combined with somatostatin in the treatment of upper gastrointestinal bleeding had a better clinical efficacy, a high success rate of hemostasis and a better clinical safety, which provided a basis for clinical treatment of non-varicose upper gastrointestinal hemorrhage.
作者
郭丹
郭建巍
Guo Dan;Guo Jianwei(Department of Gastroenterology,Beijing Haidian Hospital,Beijing 100000,China)
出处
《中国病案》
2018年第11期84-86,共3页
Chinese Medical Record
关键词
埃索美拉唑钠针剂
生长抑素
非静脉曲张
消化道出血
应用
Esomeprazole sodium injection
Somatostatin
Non-varices
Gastrointestinal hemorrhage
Application
