摘要
目的探讨妊娠期高血压疾病患者血清胱抑素与超敏C反应蛋白的相关性及对分娩结局的影响。方法选择2016年5月-2018年1月我院收治的妊娠期高血压患者50例,设为观察组,其中妊娠期高血压21例(设为GH组),轻度子痫前期16例(设为MP组),重度子痫前期13例(设为SP组);选择同期入院孕检的正常妊娠孕妇50例,设为对照组;测定2组超敏C反应蛋白、血清胱抑素、尿素氮、血清肌酐、24h尿蛋白、白蛋白水平;采用Pearson相关性分析软件上述指标水平相关性进行分析;记录并统计2组剖宫产、阴道助产、自然分娩及新生儿窒息发生率。结果观察组血清胱抑素水平与超敏C反应蛋白水平,均高于对照组(P<0.05);SP组血清胱抑素水平与超敏C反应蛋白,高于GH组和MP组(P<0.05);MP组血清胱抑素水平与超敏C反应蛋白水平,高于GH组(P<0.05);观察组血清胱抑素、超敏C反应蛋白、尿素氮、血清肌酐、24h尿蛋白水平,均高于对照组(P<0.05),观察组白蛋白,低于对照组(P<0.05);Pearson相关性分析结果表明:妊娠期高血压疾病患者超敏C反应蛋白、血清胱抑素与尿素氮、血清肌酐、24h尿蛋白水平呈正相关性(P<0.05),与白蛋白负相关(P<0.05);观察组剖宫产率、新生儿窒息率,高于对照组(P<0.05);观察组自然分娩率,低于对照组(P<0.05)。结论妊娠期高血压疾病患者血清胱抑素、超敏C反应蛋白与肾功能水平具有一定的相关性,临床上加强超敏C反应蛋白、血清胱抑素测定能反应患者肾功能受损情况,能为临床治疗干预提供依据,有助于改善妊娠结局。
Obejective To explore the correlation between serum cystatin and hypersen sitive c-reactive proteinin hypertensive disorder complicating pregnancy patients during pregnancy and its effect on the outcome of childbirth.Methods In May 2016 to January 2018, our hospital of 50 patients with hypertensive disorder complicating preg-nancy, set as observation group, 21 cases of gestational hypertension （set to GH group）, 16 cases of mild preeclampsia（set to MP group）, 13 cases of severe preeclampsia group （set to SP）; 50 normal pregnant women who were admitted tothe hospital for pregnancy test at the same time were selected as the control group. The levels of hypersensitivec-reactive protein, serum glutathione, urea nitrogen, serum creatinine, 24h urinary protein and albumin in the twogroups were measured. Pearson correlation analysis software was used to analyze the horizontal correlation of theabove indicators. The incidence rates of cesarean section, vaginal delivery, natural delivery and neonatal asphyxia were recorded.Results Serum cystatin and hypersensitive c-reactive protein in the observation group were higher than those in the control group（ 〈0.05）. Serum cystatin and hypersensitive c-reactive protein were higher in SPgroup than in GH group and MP group（ 〈0.05）. Serum cystatin and supersensitive c-reactive protein were higher inMP group than GH group（ 〈0.05）. Serum cystatin, hypersensitive c-reactive protein, urea nitrogen, serum creatinineand 24h urinary protein in the observation group were all higher than those in the control group（ 〈0.05）, and albuminin the observation group was lower than that in the control group（ 〈0.05）. Pearson correlation analysis results showthat the patients with hypertensive disorder complicating pregnancy, serum c-reactive protein, serum cystatin andurea nitrogen, serum creatinine and 24h urine protein were positively correlation（ 〈0.05）, negatively related to thealbumin（ 〈0.05）; The rates of cesarean section and neonatal asphyxia in the observation group were higher than those in the control group（ 〈0.05）. The rate of natural delivery in the observation group was lower than that in the control group（ 〈0.05）.Conclusion The serum cystatin,hypersensitive c-reactive protein in patients with hypertensivedisorder complicating pregnancy, and renal function has a certain relevance, strengthening clinical examination,serum cystatin and hypersensitive c-reactive protein can response in patients with kidney damage, providea basis forclinical treatment intervention, help to improve the pregnancy outcome.
作者
沈翠花
杨奕梅
戴芙蓉
李科珍
黄磊
康玮
Shen Cuihua;Yang Yimei;Dai Furong(Department of Obstetrics and Gynacology,Kunming maternal and child health care hospital,Kunming,Yunan 650031,China)
出处
《云南医药》
CAS
2018年第6期481-484,共4页
Medicine and Pharmacy of Yunnan
关键词
妊娠期高血压疾病
血清胱抑素
超敏C反应蛋白
相关性
Hypertensive disorder complicating pregnancy
Serum cystatin
High sensitivity C reactive protein
Correlation
