摘要
目的探讨血清透明质酸（HA）在慢性病毒性肝炎肝纤维化诊断中的临床价值。方法选取运城市中心医院2015年1月至2016年2月收治的慢性病毒性肝炎肝纤维化患者108例为研究对象，同时选取健康体检者30例作为对照组，均进行血清HA测定，分析血清HA在肝纤维化中的敏感度和特异度，并探讨血清HA与肝病病理分级、分期的关系。结果急性黄疸型肝炎、慢性肝炎轻度、慢性肝炎中度、慢性肝炎重度、肝炎后肝硬化血清HA水平为（138.76±14.92）ng/L、（90.21±6.73）ng/L、（106.29±12.35）ng/L、（365.48±25.39）ng/L、（597.24±48.11）ng/L，均高于对照组的（64.26±8.24）ng/L，差异均有统计学意义（t＝8.723、6.275、22.025、65.798、63.670，均P〈0.05），随着肝纤维化程度的增加，患者血清HA水平明显升高，血清HA与肝炎活动度分级及肝纤维化分期有一定相关性（r＝0.48、0.43，均P〈0.05），且特异度较高。结论血清HA在慢性病毒性肝炎肝纤维化诊断中具有良好的诊断价值。
Objective To investigate the clinical value of serum hyaluronic acid（HA） in the diagnosis of hepatic fibrosis in chronic viral hepatitis.Methods From January 2015 to February 2016, 108 patients with chronic viral hepatitis diagnosed by liver biopsy in Yuncheng Central Hospitalwere selected, and 30 healthy subjects were selected as controls.Serum HA was measured and the sensitivity and specificity of serum HA in the diagnosis of liver fibrosis were analyzed.The relationship between serum HA and liver pathological grade and staging were explored.Results The levels of serum HA in acute jaundice hepatitis, chronic hepatitis, mild and chronic hepatitis, moderate and chronic hepatitis, severe hepatitis and liver cirrhosis were （138.76±14.92）ng/L, （90.21±6.73）ng/L, （106.29±12.35）ng/L, （365.48 ± 25.39）ng/L, （597.24± 48.11）ng/L, respectively, which were significantly higher than （64.26±8.24）ng/L in the control group, the difference was statistically significant（t=8.723, 6.275, 22.025, 65.798, 63.670, all P〈0.05）. With the increase of liver fibrosis, serum HA level was significantly increased.Serum HA and liver inflammation activity classification and liver fibrosis staging had certain correlation（r=0.48, 0.43, all P〈0.05）, and the specificity was high.Conclusion Serum HA has a good diagnostic value in the diagnosis of hepatic fibrosis in chronic viral hepatitis.
作者
王秀丽
姚鹏
Wang Xiuli;Yao Peng(Department of Infectious Diseases,Yuncheng Central Hospital,Yuncheng,Shanxi 044000,China)
出处
《中国基层医药》
CAS
2018年第21期2819-2822,共4页
Chinese Journal of Primary Medicine and Pharmacy
