摘要
目的探讨高危型人乳头状瘤病毒(HPV)阴性子宫颈癌患者的临床病理特征。方法选取2015年4月至2017年4月间达州市中西医结合医院收治的300例子宫颈癌患者,对高危型HPV阴性和阳性患者的年龄比例、临床分期及病理类型等指标进行比较。结果 300例子宫颈癌患者中27例(9. 0%)为高危型HPV阴性,273例(91. 0%)高危型HPV阳性。高危型HPV分型检测和HC-Ⅱ法符合率为100. 0%。高危型HPV阳性子宫颈癌患者各年龄段构成比同高危型HPV阴性子宫颈癌患者比较,差异无统计学意义(P>0. 05),两类患者均以36～50岁为疾病高发年龄段。高危型HPV阴性子宫颈癌患者的腺癌比例较高危型HPV阳性组高,差异有统计学意义(P <0. 05)。高危型HPV阴性子宫颈癌患者的临床分期与高危型HPV阳性组比较,差异无统计学意义(P> 0. 05)。高危型HPV阳性子宫颈癌患者中149例行液基细胞学检测(TCT),高危型HPV阴性子宫颈癌患者中12例进行TCT检测,不同病变的构成比比较,差异无统计学意义(P> 0. 05)。结论高危型HPV分型检测在高危型HPV阴性子宫颈癌的诊断中敏感度较高,高发年龄段为36～50岁,其中,腺癌的比例较高。
Objective To study the clinicopathological features of high-risk types of HPV-negative cervical cancer. Methods The subjects of this study were 300 patients with cervical cancer treated at Dazhou Hospital of Integrated Traditional Chinese and Western Medicine from April 2015 to April 2017.Age,clinical stage,pathological type and other indicators were compared between patients with high-risk HPV-negative cervical cancer and patients with high-risk HPV-positive cervical cancer. Results Among the 300 patients,27（ 9. 0%） were patients with high-risk HPV-negative cervical cancer and 273（ 91. 0%）were high-risk HPV-positive cervical cancer. The coincidence rate was 100. 0% for high-risk HPV genotyping test and second generation of hybrid capture technology（ HC-Ⅱ） test. There was no statistically significant difference in age composition ratio between patients with high-risk HPV-negative cervical cancer and HPV-positive cervical cancer（ P〉0. 05）. Disease incidence and disease prevalence are higher among patients in age group 36 ～ 50 years old. The incidence of adenocarcinoma was higher in patients with high-risk HPV-negative cervical cancer than in patients with high-risk HPV-positive cervical cancer（ P〈0. 05）.There was no statistically significant difference in clinical stage between the two groups（ P〉0. 05）. One hundred and forty-nine patients underwent TCT test in patients with high-risk HPV-positive cervical cancer and 12 patients underwent TCT test in patients with high-risk HPV-negative cervical cancer（ P〉0. 05）.Conclusion The sensitivity of the high-risk HPV genotyping test is high for the diagnosis of high-risk HPVnegative cervical cancer. Disease incidence and disease prevalence are higher among patients in age group36 ～ 50 years old. The proportion of adenocarcinoma is high.
作者
刘常燕
肖琳
王宇
勒健美
LIU Chang-Yan;XIAO Lin;WANG Yu;LE Jian-mei(Department of Obstetrics and Gynecology,Dazhou Hospital of Integrated Traditional Chinese and Western Medicine,Dazhou 635000,China)
出处
《中国肿瘤临床与康复》
2018年第11期1329-1332,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
子宫颈肿瘤
高危型HPV阴性
病理特征
Cervical neoplasms
High-risk negative HPV
Pathological characteristics
