摘要
目的探讨阿加曲班联合阿司匹林对老年急性脑梗死病人炎症因子水平和神经功能恢复的影响。方法将2015~2016年我院收治的50例老年急性脑梗死病人随机分为观察组及对照组,每组25例。对照组采用常规治疗和拜阿司匹林治疗,观察组在对照组基础上加用阿加曲班治疗。检测所有病人治疗前后凝血指标、炎症因子和磷脂酶A2水平,比较2组治疗前后美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分的变化。结果治疗后,2组的纤维蛋白原(FIB)、炎症因子、磷脂酶A2水平和NIHSS评分均较治疗前显著降低(P<0.05),凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)均较治疗前延长(P<0.05),2组间比较差异亦有统计学意义(P<0.05)。2组病人均未出现脑出血等严重的不良事件。结论阿加曲班联合拜阿司匹林治疗老年急性脑梗死可降低炎症因子水平,改善凝血功能,有效提高病人神经功能。
Objective To investigate the effect of argatroban combined with aspirin on the levels of inflammatory factors and the neurological function in the elderly patients with acute cerebral infarction（ACI）.Methods A total of fifty elderly patients with ACI admitted to our hospital from January 2015 to December 2016 were enrolled and randomly divided into observation group and control group,with 25 cases in each group.The control group was given conventional treatment and aspirin,and the observation group was given argatroban based on the treatment of control group.The levels of coagulation index,inflammatory factors,phospholipase A2（PLA2） and the score of National Institute of Health stroke scale（NIHSS） before and after the treatment were observed and compared between the two groups.Results After treatment,the levels of fibrinogen（FIB）,inflammatory factors,PLA2 and the NIHSS score were significantly decreased and the levels of activated partial thromboplastin time（APTT）,prothrombin time（PT） were significantly prolonged in observation group than those before treatment and those in control group（P〈0.05）.No serious adverse events such as cerebral hemorrhage occurred in two groups.Conclusions Argatroban combined with aspirin can decrease the levels of inflammatory factors,improve coagulation status and the neurological function effectively.
作者
房宇
倪杰
樊华
FANG Yu(Department of Medicin;NI Jie.De partment of Emergency,Drum-Tower Hospital,Affiliated to Nanjing University Medical college,Nanjing 210008,China;FAN Hua.Geriatric Hospital of Nanjing Medical University,Nanjing 210024,China)
出处
《实用老年医学》
CAS
2018年第11期1050-1053,共4页
Practical Geriatrics
关键词
阿加曲班
阿司匹林
急性脑梗死
神经功能
炎症因子
argatroban
aspirin
acute cerebral infarction
nerve function
inflammatory factors
