摘要
[目的]研究复方清降保龄液联合多烯磷脂酰胆碱胶囊治疗非酒精性脂肪肝病(NAFLD)的临床疗效及对患者血脂、肝功能和肝纤维化指标的影响,旨在为更好地治疗NAFLD痰瘀互结证患者提供有效的理论依据。[方法]选取2015年11月~2017年11月期间本院收治的100例NAFLD痰瘀互结证患者作为研究对象,按照随机数字表法分成对照组与中药组,每组50例,对照组患者采用多烯磷脂酰胆碱胶囊治疗,中药组患者采用复方清降保龄液联合多烯磷脂酰胆碱胶囊治疗。观察并比较不同治疗方式对2组患者的临床疗效以及对血脂、肝功能、肝纤维化指标及不良反应情况。[结果](1)中药组治疗后总有效率明显高于对照组(92.00%vs.70.00%)(P<0.05);(2)2组治疗前甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDLC)水平比较,差异无统计学意义;2组治疗后TG、TC及LDL-C水平均降低,HDL-C水平升高,且中药组改变幅度明显大于对照组(P<0.05);(3)2组治疗前丙氨酸转氨酶(ALT)、天氨酸转氨酶(AST)、γ-谷氨酰转肽酶(γ-GT)水平比较,差异无统计学意义;2组治疗后ALT、AST、γ-GT水平均降低,且中药组改变幅度明显大于对照组(P<0.05);(4)2组治疗前Ⅲ型前胶原(PC-Ⅲ)、层粘连蛋白(LN)、透明质酸(HA)水平比较,差异无统计学意义;2组治疗后PC-Ⅲ、LN、HA水平均降低,且中药组改变幅度明显大于对照组(P<0.05);(5)2组均未发现明显不良反应。[结论]复方清降保龄液联合多烯磷脂酰胆碱胶囊治疗NAFLD痰瘀互结证患者可显著提高临床疗效,可改善血脂、肝功能及肝纤维化,无明显不良反应,安全性好。
[Objective]To investigate the elf polyene phosphatidylcholine capsules on serum coholic fatty liver disease（NAFLD）,aiming to ect of comp lipid, liver provide an ound Qingjiang Bao function effective and liver theoretic ling decoction combined with brosis of patients with nonal- basis for better treatment of NAFLD patients with intermingled phlegm and blood stasis syndrome. [-Methods]A total of 100 NAFLD patients with intermingled phlegm and blood stasis syndrome treated in our hospital f to November 2017 were selected and equally divided into two groups according to ble. The control group received the polyene phosphatidylcholine capsules, based on ceived the compound Qingjiang Baoling decoction. Then the clinical efficacy, blood the rom November 2015 random number ta- this,the TCM group re- lipid, liver function, liverfibrosis indexes and adverse reactions of two groups were observed and compared. [Results]① The total ef- fective rate of TCM group after treatment was significantly higher than that of the control group（92.00%vs. 70. O0 %, P〈0.05） ② The levels of triglyceride （TG）, total cholesterol （TC）, high-density lipoprotein cholesterol （HDL-C）and low-density lipoprotein cholesterol （LDL-C）had no difference before treat- ment. After treatment,the levels of TG, TC, and LDL-C were decreased and the level of HDL-C was in- creased,while both changes were more significant in the TCM group than those in the control group（P 〈0.05）③ The levels of alanine aminotransferase （ALT）, aspartate aminotransferase （AST）,γ-glutamyl transpeptidase（T-GT）had no difference before treatment, which were decreased after treatment, and were lower in the TCM group than those in the control group（P〈0.05）;④The levels of precollagen III（PC- III） ,laminin（LN）and hyaluronie acid（HA）had no difference before treatment, which were decreased after treatment,and were lower in the TCM group than those in the control group（P〈0.05） ;⑤ No obvious ad- verse reactions were found in both groups, l-Conclusion]The compound Qingjiang I3aoling decoction com- bined with polyene phosphatidylcholine capsules can safely and effectively ameliorate the blood lipids,liver function and liver fibrosis for NAFLD patients with intermingled phlegm and blood stasis syndrome, which has no obvious adverse reactions.
作者
杨旻昕
洪庆祥
岑怡
YANG Min-xin;HONG Qing-xiang;CEN Yi(Department of Traditional Chinese Medicine,Shanghai Eighth People＇s Hospital,Shanghai 200235,China）Corresponding author.YANG Min-xin,E-mail ~ xinxinyang198@ 163.corn)
出处
《中国中西医结合消化杂志》
CAS
2018年第10期829-833,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
上海市基层名老中医专家传承研究工作室建设项目(No:JCZYGZS-009)
上海市徐汇区青年人才配套课题
关键词
复方清降保龄液
多烯磷脂酰胆碱
非酒精性脂肪肝病
痰瘀互结证
临床疗效
compound Qingjiang Baoling decoction
polyene phosphatidylcholine
NAFLD
intermingledphlegm and blood stasis syndrome
clinical efficacy
