摘要
目的分析血清同型半胱氨酸(Hcy)水平对冠心病并发缺血性与出血性脑卒中的影响。方法回顾性分析2014年1月至2015年8月本院收治的171例住院患者Hcy水平信息及相关临床资料,随访2.5年,分析血清Hcy水平对冠心病并发缺血性与出血性脑卒中的影响。结果 171例患者中Hcy高表达(Hcy高表达组)65例,非Hcy高表达(非Hcy高表达组)106例。Hcy高表达组患者中结局事件为冠心病并发缺血性脑卒中13例(20.00%),结局事件为冠心病并发出血性脑卒中16例(24.62%);与非Hcy高表达组比较,Hcy高表达组患者并发缺血性和出血性脑卒中结局事件发生率更高,差异均有统计学意义(P<0.05)。Hcy高表达、体质量指数(BMI)≥25kg/m^2及冠心病病程≥5年3个因素与并发缺血性脑卒中呈正相关,Hcy高表达、BMI≥25kg/m^2、高血压及冠心病病程≥5年4个因素与并发出血性脑卒中呈正相关。结论 Hcy高表达可作为独立预测因子提示冠心病患者并发缺血性和出血性脑卒中的风险增加,同时,血压状态、肥胖情况及冠心病本身病程长短也会对并发2类脑卒中预后有影响。
Objective To analyze the effect of serum homocysteine（Hcy）level on coronary heart disease complicated with ischemic and hemorrhagic stroke.Methods A retrospective analysis of 171 hospitalized patients with Hcy level information and related clinical data from January 2014 to August 2015 was conducted.Follow-up for 2.5 years was conducted to analyze the impact of serum Hcy level on coronary heart disease complicated with ischemic and hemorrhagic stroke.Results Among 171 patients,65 had overexpression of Hcy（overexpression of Hcy group）,106 had non-overexpression of Hcy（overexpression of non-Hcy group）.13 cases in Hcy overexpression group had the outcomes of coronary heart disease complicated with ischemic stroke（20.00%）and 16 cases had coronary heart disease complicated with hemorrhagic stroke（24.62%）.Compared with non-Hcy overexpression group,the incidence of ischemic and hemorrhagic stroke outcomes in Hcy overexpression group was higher,and the difference was statistically significant（P＜0.05）.Overexpression of Hcy,BMI（＞25 kg/m2）and duration of coronary heart disease（＞5 years）were positively correlated with ischemic stroke.Overexpression of Hcy,BMI（＞25 kg/m2）,hypertension and duration of coronary heart disease（＞5 years）were positively correlated with hemorrhagic stroke.Conclusion The overexpression of Hcy can be used as an independent predictor of the increased risk of ischemic and hemorrhagic stroke in patients with coronary heart disease.At the same time,blood pressure status,obesity and the duration of coronary heart disease itself also have an impact on the prognosis of two types of stroke.
作者
郝爱军
HAO Aijun(Department of Clinical Laboratory,Xiangyang Traditional Chinese Medicine Hospital,Xiangyang,Hubei 441000,China)
出处
《国际检验医学杂志》
CAS
2018年第23期2957-2959,共3页
International Journal of Laboratory Medicine
关键词
高半胱氨酸
冠心病
卒中
预测
homocysteine
coronary disease
stroke
forecasting
