摘要
骨质疏松症是以全身骨量减少、骨组织显微结构退化为特征的,致使骨的脆性增加以及易于发生骨折的一种全身性骨骼疾病。其发病机制尚未完全明了,现已知与多种因素有关,如年龄、内分泌、遗传因素等。骨质疏松症主要发病机制是成骨细胞与破骨细胞活性及分化失衡所导致的骨代谢失衡。目前对骨质疏松症的靶向治疗研究领域涉及激素靶向、药物靶向、分子靶向治疗等。但当前靶向治疗方法尚未完全成熟,所导致的临床不良反应限制其应用进展,仍有许多问题有待解决。本文主要对骨质疏松症与激素调节、骨基质代谢、破骨细胞的关系以及目前骨质疏松症的靶向治疗进展作一综述,为进一步治疗骨质疏松症提供思路与方法。
Osteoporosis（OP） is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Its pathogenesis is not completely clear, that is associated with age, endocrine, genetics and so on. The main pathogenesis of osteoporosis is the imbalance of bone metabolism caused by osteoblast and osteoclast activity and differentiation. Current research about targeted therapy for osteoporosis involves hormone-targeted, drug-targeted, molecular-targeted therapies. However, there is not fully mature targeted therapy for osteoporosis, and its clinical side effects limit its further development. This paper summarizes the relationship between osteoporosis and hormonal regulation, the metabolism of bone matrix, osteoclasts, and concludes the targeted therapy of osteoporosis methods, to provide new ideas and methods for the treatment of osteoporosis.
作者
张坛
钱宇
ZHANG Tan;QIAN Yu(Department of Orthopedics,Shaoxing People＇s Hospital,Shaoxing Hospital of Zhejiang University School of Medicine Shaoxing 312300,Zhejiang,China)
出处
《中华骨与关节外科杂志》
2018年第10期783-790,共8页
Chinese Journal of Bone and Joint Surgery
基金
国家自然科学基金(81871801
81572126)
浙江省自然科学基金(LY15H060005)
浙江省自然科学青年基金(LQ16H160013)
绍兴市公益性技术应用研究计划(2014B70076)
关键词
骨质疏松
破骨细胞
靶向治疗
Osteoporosis
Osteoclasts
Targeted Therapy
