摘要
沙门菌是一种重要的人兽共患病原菌,不仅可以感染畜禽,而且还可以感染人类。鸡白痢沙门菌、鸡伤寒沙门菌、肠炎沙门菌等感染家禽后可以引起禽沙门菌病,导致隐性带菌感染,甚至引发死亡,给养禽业带来巨大的经济损失。沙门菌感染的家禽及其污染的产品是食源性沙门菌的主要来源之一,不仅阻碍了家禽相关产业的发展,而且也对人类健康构成了巨大威胁。疫苗的使用是防控沙门菌的手段之一,但是疫苗并不能完全有效地控制沙门菌的感染和传播。阐明沙门菌诱导家禽免疫应答规律有助于疫苗的理性设计。文章就沙门菌在家禽中的免疫应答研究进展进行了总结,为禽沙门菌疫苗的研制提供参考。
Salmonella is an important zoonotic pathogen, which can infect not only livestock but also humans. Salmonella serotypes including Salmonella pullorum, Salmonella gallinarum and Salmonella Enteritidis can infect chicken and cause avian salmonellosis, which leading to great economic losses in poultry industry. Salmonella-infected poultry and contaminated products are important sources of foodborne pathogens, which does not only hinder the development of poultry-industry, hut also poses a great threat to human health. Vaccination is an effective strategy to control avian Salmonella infection. The development and design of vaccine require an understanding of the immune response. In this review, we summarize the research advance in avian immunity to Salmonella.
作者
康喜龙
唐娟
焦扬
王超
胡茂志
周晓辉
潘志明
焦新安
KANG Xilong;TANG Juan;JIAO Yang;WANG Chao;HU Maozhi;ZHOU Xiaohui;PAN Zhiming;JIAO Xin＇an(Jiangsu Key Laboratory of Zoonosis,Yangzhou University,Yangzhou,Jiangsu 225009;Jiangsu Co-innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou University,Yangzhou,Jiangsu 225009;Key Laboratory of Prevention and Control of Biological Hazard Factors（Animal Origin）for Agrifood Safety and Quality,MOA,Yangzhou University,Yangzhou,Jiangsu 225009;Joint International Research Laboratory of Agriculture and Agri-product Safety of the Ministry of Education,Yangzhou,Jiangsu 225009)
出处
《中国家禽》
北大核心
2018年第21期1-6,共6页
China Poultry
基金
国家重点研发计划课题(2016YFD0501607)
公益性行业(农业)科研专项(201403054)
国家自然科学基金项目(31320103907
31230070)
扬州大学科技创新团队
江苏省高校优势学科建设工程资助项目(PAPD)
关键词
沙门菌
家禽
天然免疫
获得性免疫
免疫逃避
Salmonella
avian
innate immunity
adaptive immunity
immune evasion
