摘要
[目的]观察通心络胶囊与针刺联合纳洛酮治疗急性脑梗死疗效。[方法]使用随机平行对照方法,将538例住院患者按病志号抽签方法随机分为两组,抗血小板、溶栓、抗凝。对照组269例纳洛酮,2～4mg/次,1次/d,静滴,根据病情调整。治疗组269例通心络胶囊,0.52g/次,3次/d;3d后针刺,选风池、百会、地仓、下关、四白、颊车、迎香、风池;肩髃、合谷、曲池、内关;委中、足三里、解溪、风市、阳陵泉;吞咽反呛加水沟、合谷、风池;语言障碍加四神聪、廉泉;呃逆加劳宫、内关、足三里、鱼腰;小便失禁加用气海、三阴交、归来、中极、关元,得气后留针20～30min,1次/d,疗程间休息3～5d;纳洛酮治疗同对照组。连续治疗10d为1疗程。观测临床表现、溶血磷脂酸、S100蛋白、神经功能缺损评分(NIHSS评分)、生活自理能力评分、不良反应。连续治疗2疗程(20d),判定疗效。[结果]治疗组显效170例,有效80例,无效19例,总有效率92.94%;对照组显效142例,有效62例,无效65例,总有效率75.84%;治疗组疗效优于对照组(P<0.01)。溶血磷脂酸、S100蛋白、NIHSS评分、生活自理能力评分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]通心络胶囊与针刺联合纳洛酮治疗急性脑梗死,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Tongxinluo capsule combined with acupuncture and naloxone in treating acute cerebral infarction. [Methods] 538 hospitalized patients were randomly divided into two groups by lottery according to their disease symbols. They were antiplatelet, thrombolytic and anticoagulant. The control group consisted of 269 cases of naloxone, 2 to 4 mg/times, 1 times/d, and intravenous drip according to the condition. Treatment group 269 cases, Tongxinluo, 0.52 g/time, three times a day; 3 days later, acupuncture, selected wind pool, Baihui, canyon, Xiaguan, Sibai, cheek car, Yingxiang, wind pool; shoulder condyle, Hegu, Quchi, Neiguan; Central Committee, Zusanli, Xiexi, Fengshi, Yanglingquan;swallowing back and choking ditch, Hegu, Fengchi; language disorders plus four Shensheng, honest Quan;hiccup plus Lao Gong, Neiguan, Zusanli, Fish waist; urinary incontinence plus Qihai, Sanyinjiao, Hui,Zhongji, Guanyuan, after Qi retention needle 20～30 minutes, once a day, treatment interval 3～5 days;naloxone treatment with the control group. Continuous treatment of 10 d for 1 courses. Clinical manifestations,lysophosphatidic acid, S100 protein, neurological deficit score（NIHSS）, self-care the treatment group, 170 cases were markedly effective, 80 cases were effective, 19 cases were ineffective, the total effective rat ability score, adverse reactions were observed. Continuous treatment of 2 courses（20 d）, determine the curative effect. [Results] In the treatment group, 170 cases were markedly effective, 80 cases were effective, 19 cases were ineffective, the total effective rate was 92.94%; in the control group, 142 cases were markedly effective,62 cases were effective, 65 cases were ineffective, the total effective rate was 75.84%; the curative effect of the treatment group was better than that of the control group（P〈0.01）. Lysophosphatidic acid, S100 protein,NIHSS score and self-care ability score were improved in both groups（P〈0.01）. The improvement in treatment group was better than that in control group（P〈0.01）. [Conclusion] Tongxinluo Capsule combined with acupuncture and naloxone in the treatment of acute cerebral infarction has satisfactory curative effect without serious adverse reactions and is worth popularizing.
作者
黄权清
HUANG Quanqing(Fogang Hospital of Traditional Chinese Medieine.Fogang 511600,Guangdong,China)
出处
《实用中医内科杂志》
2018年第9期38-41,共4页
Journal of Practical Traditional Chinese Internal Medicine
关键词
急性脑梗死
中风
针刺
通心络胶囊
纳洛酮
溶血磷脂酸
S100蛋白
神经功能缺损评分
生活自理能力评分
中药复方
随机平行对照研究
acute cerebral infarction
stroke
acupuncture
Tongxinluo
Naloxone
lysophosphatidie acid
S100 protein
neurological deficit score
Self-care ability score
Chinese herbal compound
randomized parallel controlled study
