摘要
目的 探讨同期放疗联合内分泌治疗对中晚期前列腺癌临床疗效、并发症及生存质量的影响.方法 选取于2012年4月至2014年4月在本院收治的86例中晚期前列腺癌患者作为研究对象.根据不同的治疗方法将其随机分成观察组（43例）和对照组（43例）,对照组患者给予三维适形放射法进行治疗,观察组给予同期放疗联合内分泌治疗.对比观察两组患者治疗后临床疗效、并发症发生率和术后生存质量.结果 观察组治疗后完全缓解占比37.21％（16/43）,总有效62.79％（27/43）,显著高于对照组16.28％ （7/43）、34.88％（15/43）（P＜0.05）;两组患者在治疗后均有并发症发生,但观察组总并发症发生率显著低于对照组（P＜0.05）;治疗前两组患者前列腺癌症状评分表（expanded prostate cancer index composite,EPIC）各指标差异均无统计学意义,治疗后两组患者EPIC各指标均有明显下降,且观察组下降幅度显著小于对照组（P＜0.05）;治疗前两组患者血清PSA以及最大尿流率差异均无统计学意义,治疗后两组患者PSA均较治疗前有显著下降,且最大尿流率均较治疗前有显著升高,但观察组改善幅度均明显优于对照组（P＜0.05）.结论 同期放疗联合内分泌治疗对中晚期前列腺癌临床疗效显著,同时有效降低并发症,提高患者生存质量,并有效降低患者血清PSA水平以及有效提高患者最大尿流率,值得临床借鉴参考.
Objective To explore clinical efficacy,complications and quality of life of the radiotherapy combined with endocrine therapy for advanced prostate cancer.Methods From April 2012 to April 2014,86 cases of advanced prostate cancer patients in our hospital were selected as the research object.According to the different treatment methods,all patients were randomly divided into observation group （43 cases） and control group （43 cases）,the control group was treated with three-dimensional conformal radiation treatment,observation group received radiotherapy combined with endocrine treatment.Clinical efficacy after treatment,complications and quality of life were compared between the two groups.Results The observation group after complete remission accounting for 37.21％ （16/43）,the total effective 62.79％ （27/43） was significantly higher than the control group 16.28％ （7/43）,34.88％ （15/43） （P ＜ 0.05）.Two group of patients had complications after treatment,but the total complication rate of observation group was significantly lower than the control group （P ＜ 0.05）.The indexes of the two groups before treatment patients with expanded prostate cancer index composite（EPIC） had no significant difference,after treatment of each index of two groups of patients with EPIC decreased significantly,and the observation group decreased more significantly than the control group （P ＜ 0.05）.Serum PSA and maximum urinary flow rate of two groups of patients before treatment were no significant difference between the two groups after treatment,PSA was significantly lower than before treatment,and the maximum urine flow rate compared with before treatment were significantly increased,but the observation group improved significantly better than the control group （P ＜ 0.05）.Conclusions Radiotherapy combined with endocrine therapy has some advantages on the clinical efficacy of advanced prostate cancer,complications reduction,and improvement of survival quality,and effectively reduces the level of serum PSA and improves maximum urinary flow rate.
作者
潘炜
Pan Wei(Department of Urology,the People＇s Hospital of Huangpi District,Wuhan 430300,China)
出处
《国际泌尿系统杂志》
2018年第6期900-903,共4页
International Journal of Urology and Nephrology
关键词
前列腺肿瘤
放射疗法
生活质量
Prostatic Neoplasms
Radiotherapy
Quality of Life
