摘要
目的研究奥氮平与喹硫平治疗老年期精神障碍的临床效果。方法 50例老年期精神障碍患者,根据随机分组法分为观察组与对照组,各25例。观察组采用奥氮平进行治疗,对照组采用喹硫平进行治疗,比较两组治疗效果及不良反应发生情况。结果观察组总有效率96.00%与对照组的88.00%比较,差异无统计学意义(P>0.05)。观察组不良反应发生率为12.00%,低于对照组的36.00%,差异有统计学意义(P<0.05)。结论在老年期精神障碍患者的治疗中,奥氮平与喹硫平疗效相当,但采用奥氮平治疗安全性较高,临床应根据患者实际病情为患者选用合理药物。
Objective To study the clinical effect of olanzapine and quetiapine in the treatment of senile mental disorders. Methods A total of 50 senile patients with mental disorders were randomly divided into observation group and control group, with 25 cases in each group. The observation group was treated with olanzapine, and the control group was treated with quetiapine. The treatment effect and occurrence of adverse reactions between the two groups was compared. Results The observation group had no statistically significant difference in total effective rate as 96.00%, comparing with 88.00% in the control group（P〉0.05）. The observation group had lower incidence of adverse reactions as 12.00% than 36.00% in the control group, and the difference was statistically significant（P〈0.05）. Conclusion In the treatment of senile patients with mental disorders, olanzapine and quetiapine have the same efficacy, but the safety of olanzapine is higher. Clinically, appropriate drugs should be selected according to the actual condition of the patient.
作者
李楚清
LI Chu-qing(Baiyun Jingkang Hospital,Guangzhou 510445,China)
出处
《中国实用医药》
2018年第33期110-111,共2页
China Practical Medicine
关键词
奥氮平
喹硫平
老年期精神障碍
Olanzapine
Quetiapine
Senile mental disorders
