摘要
报道30例血清总胆固醇7.76mmol/L以上的非家族性高胆固醇血症(N-FH)患者的LDL受体水平及内分泌功能,结果表明,高胆固醇血症发生可能受内分泌功能失衡的影响,其中胰岛素、生长激素水平增高。雌激素和睾酮水平失调可能起一定作用。同时,前列腺素代谢物TXB_2异常增高,TXB_2和6酮前列环素比值明显上升,可使血液呈高凝状态,增加心肌梗塞和脑血栓发生的机率.N-FH患者LDL受体水平增高,除自身代偿功能外,可能受胰岛素、雌激素等的调节。
The low-density lipoprotein (LDL) receptor level and endocrine function were studied in 30 cases of non-familial hypercholesterolemia. The results showed that endocrine dysfunction may play a role in the pathogenesis of hyper-
cholesterolemia, for example, the elevation of insulin and growth hormone level, the abnormal ratio of estrogen and testosterone. In addition, the increase of TXB2 and 6-ketone prostacyclihe may make the blood hypercoagulative, raise the incidence of myocardial infarction and cerebral thrombosis. Except the physiologic compensation the LDL receptor level in non-familial hypercholesterolemia may also be regulated by insulin and estrogen.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1991年第2期67-70,共4页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目
关键词
高胆固醇血症
非家族性
LDL受体
Non-familial hypercholesterolemia Low-density lipoprotein receptor
