摘要
目的 :探讨表皮生长因子受体 (EGFR)和肿瘤转移抑制基因nm2 3H1在胆管癌的表达及其意义。方法 :采用免疫组化SABC法检测 2 1例胆管癌及 15例胆管炎组织中EGFR、nm2 3H1基因蛋白产物 ,并分析其意义。结果 :胆管癌中nm2 3H1阳性表达率低于胆管炎组织 (P <0 .0 5 ) ,而EGFR在胆管癌组织中的阳性表达率则显著升高 (P <0 .0 1) ,nm2 3H1的表达与胆管癌TNM分期呈负相关 (P <0 .0 1)。结论 :EGFR的高表达和nm2 3H1的低表达参与胆管癌的发生、发展。
Objective:To evaluate the expression of EGFR and gene nm23H1 and their relation to the tumor oncogenesis and progress of cholangiocarcinoma.Methods:SABC immunohistochemistry was used to detect the expression of EGFR and nm23H1 in cholangiocarcinoma and cholangitis tissue.Results:The positive rate of nm23H1 in cholangiocarcinoma was lower than cholangitis(P<0.05),while that of EGFR increased significantly(P<0.05).The expression of nm23H1 was negtive related to tumor TNM stage (P<0.05).Conclusion:It is suggested that over expression of EGFR and lower expression of nm23H1 is involved in the oncogenesis and progress of cholangiocarcinoma
出处
《中国现代普通外科进展》
CAS
2002年第3期172-173,共2页
Chinese Journal of Current Advances in General Surgery
