摘要
目的 探讨某些环境因素对溃疡性结肠炎 (UC)的致病作用。方法 回顾性统计近10年UC住院患者病历。设计表格 ,对 9个项目由专人进行电话调查。非UC对照组亦填写此表格。UC患者组共 10 1例 ,初发平均年龄 ( 3 9.3 5± 14 .94)岁 ,男性 5 6例 ,女性 45例。非UC对照组共 97名 ,平均年龄 ( 3 8.74± 14 .46)岁 ,男性 5 2名 ,女性 45名。UC多因素致病性分析采用Logistic回归分析。结果 UC组中无母乳喂养史比例 2 6/10 1( 2 5 .7%) ,不吸烟者 (含戒烟者 )比例 90 /10 1( 89.1%) ,服用避孕药比例 16/10 1( 15 .8%)均显著高于非UC对照组比例 (P <0 .0 1)。采用后退剔除程序方法进行Logistic回归分析 ,最后进入模型的 3个变量为哺乳史 (OR :0 .2 76,95 %CI:0 .185～ 0 .411) ,吸烟史 (OR :4.5 48,95 %CI:1.895～ 10 .915 ) ,服用避孕药史 (OR :4.2 73 ,95 %CI:1.0 2 6～ 17.798)。 5 7例患者多次复发 ,初发及复发诱因均主要为饮食不当、劳累、精神紧张等。 3例女性患者在产后 2个月内发病。结论 无或缺乏母乳喂养、非吸烟或戒烟及服用避孕药为UC的危险因素 ;饮食不当、劳累。
Objective To investigate the relationship of environmental factors and the etiology of ulcerative colitis(UC).Methods 101 patients with UC and 97 controls had completed one questionnaire and researched for nine subjects. The data were analysed with Logistic Regression.Results The rate of non smoking(89.1%), oral contraceptive use(15.8%)and non breast feeding(25.7%) in UC group were significantly higher than that in control group( P <0.01).Three factors entered the evaluation as risk factors in Logistic Regression analysis. They were breast feeding(OR=0.276,95% CI:0.185～.411),smoking(OR=4.548,95% CI:1.895 10.915)and oral contraceptive use (OR=4.273,95% CI:1.026～17.798).57 cases (56.4%) relapsed in later years. The common predisposing causes were unsuitable foods, mental or physical distention. Three women were attacked by UC just after delivery.Conclusions Smoking, oral contracepive use and breast feeding play an important role on the pathogenesis of UC;Unsuitable foods, mental or physical distention and even pregnancy may be risk factors for UC.
出处
《临床内科杂志》
CAS
北大核心
2002年第5期350-352,共3页
Journal of Clinical Internal Medicine
