摘要
目的探讨米非司酮对围绝经期功血的治疗作用及其对子宫内膜的影响。方法对无禁忌症 ,并自愿接受米非司酮保守治疗的围绝经期功能性子宫出血患者 3 1例 ,分别于治疗前、后对照阴道 B超测量内膜厚度、刮宫组织病理检查 ,随访观察月经恢复情况及其治疗效果。结果 B超测量 :子宫内膜厚度变薄 ,用药前为 (5 .7± 0 .2 ) mm,用药后为 (2 .5± 0 .3 ) mm ,用药前后比较 ,有显著性差异 (P<0 .0 5 )。组织病理 :腺上皮呈增生早、中期改变 ,间质改变突出 ,间质致密 ,水肿消失 ,上皮与间质均未见到异型细胞。所有患者用药期间全部闭经 ,停药后月经恢复 2 2～ 70天 ,平均 3 7天 ;月经稀发、量少 4例 ,3例分别于停药第 6、9、9个月绝经。治疗总有效率 10 0 % ,2年治愈率 78%。结论米非司酮可有效抑制子宫内膜生长 。
Objective To investigate the effect of mifepristone on dysfunctional uterine bleeding during peri menopausal period and on endometrium.Methods Endometrial thickness was measured based on Ultrasound,endometrial tissues obtained from dilatation and curettage before and after treatment was tested for 31 cases of dysfunctional uterine bleeding during peri menopausal period who volunteered to be treated by mifepristone.The changes of menstruation were observed.Results According to Ultrasound,endometrial thickness became thin from (5.7±0.2) mm to (2.5± 0.3) mm because of mifepristone,with significant differences(P<0.05).Histomorphological evaluation showed early and middle period hyperplasia changes of glandular epithelium,and obvious changes of interstitial which was dense.Edema disappeared and no strange cells were seen in epithelia and interstitial.Amenorrhea occurred in all patients during administrating mifepristone but menstruation recovered for 22～70 days,on an average of 37 days,after stopping mifepristone.Menstruation was scarce and the volume was less in 4 cases.Menopause happened in 3 cases at sixth,ninth and ninth months,respectively,after stopping mifepristone.The overall effective rate was 100% and 2 year curing rate was 78%.Conclusion Mifepristone can effectively inhibit the growth of endometrium and treat dysfunctional uterine bleeding during peri menopausal period,with satisfying result.
出处
《中国综合临床》
北大核心
2002年第10期945-946,共2页
Clinical Medicine of China
关键词
米非司酮
围绝经期功血
治疗作用
子宫内膜
Dysfunctional uterine bleeding
Peri menopausal period
Mifepristone
Endometrium
