摘要
Cystatin C, a protease inhibitor with widespread distribution,is upregulated i n response to injury. Levels are elevated in the brains of patients with Alzheim er disease (AD). We compared frequencies for the CST 3 exon 1 polymorphism in pa tients with AD and controls. A proportional odds model indicated that the CST 3 A and APOE4 combination carried a high risk: a 14-fold elevation for men and 16 -fold for women. These risks apply to risk at ages older than 64 years and to a shift in onset to ages younger than 65 years.
Cystatin C, a protease inhibitor with widespread distribution,is upregulated i n response to injury. Levels are elevated in the brains of patients with Alzheim er disease (AD). We compared frequencies for the CST 3 exon 1 polymorphism in pa tients with AD and controls. A proportional odds model indicated that the CST 3 A and APOE4 combination carried a high risk: a 14-fold elevation for men and 16 -fold for women. These risks apply to risk at ages older than 64 years and to a shift in onset to ages younger than 65 years.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第8期51-52,共2页
Digest of the World Core Medical Journals:Clinical Neurology
