期刊文献+

20q13.2拷贝数改变与晚期卵巢癌的关系——组织微阵列分析

Association of 20q13.2 copy number chang-es with the advanced stage of ovarian cancer -Tissue microarray analysis
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摘要 Over representations in 20q have been reported in a number of ovarian cancers by comparative genomic hybridization. In order to study the relation of the incr eased copy number of 20q13.2 with tumor phenotype in ovarian cancer, we applied FISH on a tissue microarray. The TMA technology enables us to analyze a large nu mber of different malignancy, histology, stage and grade tumors. Overall, the fr equency of 20q13.2 alterations in epithelial ovarian cancer was 25.50%(10.74%g ains and 14.76%amplifications). There was not statistically significant differe nce between the frequencies of 20q13.2 copy number changes in different grade tu mors. The frequency of gains and amplifications increased significantly from sta ge I to stage II to stage III tumors. Our results showed strong association betw een increases 20q13.2 copies and advanced tumor stage. We concluded that genetic alterations in 20q13.2 may be of prognostic significance for stage progression of the ovarian cancer. Over representations in 20q have been reported in a number of ovarian cancers by comparative genomic hybridization. In order to study the relation of the incr eased copy number of 20q13.2 with tumor phenotype in ovarian cancer, we applied FISH on a tissue microarray. The TMA technology enables us to analyze a large nu mber of different malignancy, histology, stage and grade tumors. Overall, the fr equency of 20q13.2 alterations in epithelial ovarian cancer was 25.50%(10.74%g ains and 14.76%amplifications). There was not statistically significant differe nce between the frequencies of 20q13.2 copy number changes in different grade tu mors. The frequency of gains and amplifications increased significantly from sta ge I to stage II to stage III tumors. Our results showed strong association betw een increases 20q13.2 copies and advanced tumor stage. We concluded that genetic alterations in 20q13.2 may be of prognostic significance for stage progression of the ovarian cancer.
出处 《世界核心医学期刊文摘(妇产科学分册)》 2005年第5期18-19,共2页 Core Journal in Obstetrics/Gynecology
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