摘要
BACKGROUND AND OBJECTIVE: To evaluate the prevalence of hemodynamically signif icant carotid artery stenosis, peripapillary blood flow, and serologic abnormali ties in a pilot study among patients with glaucoma. PATIENTS AND METHODS:All sub jects underwent complete eye examination, standard automated perimetry, carotid Doppler ultrasonography, serum laboratory testing, and scanning laser Doppler fl owmetry (SLDF). Subjects were subdivided into two groups based on glaucoma subty pe (normal-tension vs primary openangle glaucoma) and severity (mild vs moderat e-advanced). RESULTS: Twenty eyes of 20 patients with associated glaucomatous v isual field loss were enrolled. No significant differences in age, gender, intra ocular pressure, systemic comorbidity, number of antiglaucoma medications, and p rior filtration surgery were observed between the groups based on the type and s everity of glaucoma. The prevalence of clinically significant (>70%) carotid st enosis, mean peripapillary blood flow assessed by SLDF, mean erythrocyte sedimen tation rate, mean hematocrit, mean hemoglobin, and positive FTA-ABS was similar in both groups. Severity of glaucomatous damage as determined by visual field m ean defect did not correlate with the degree of carotid artery stenosis (R2< 0.0 001, P = 0.99) or peripapillary blood flow derived from mean SLDF (R2=0.000 5, P =0.92). CONCLUSION: Data from this pilot study demonstrate that the prevalence o f hemodynamically significant carotid stenosis, peripapillary blood flow, and se rologic abnormalities are similar in patients with normal-tension and primary o pen-angle glaucoma, and do not correlate with glaucoma severity.
BACKGROUND AND OBJECTIVE: To evaluate the prevalence of hemodynamically signif icant carotid artery stenosis, peripapillary blood flow, and serologic abnormali ties in a pilot study among patients with glaucoma. PATIENTS AND METHODS:All sub jects underwent complete eye examination, standard automated perimetry, carotid Doppler ultrasonography, serum laboratory testing, and scanning laser Doppler fl owmetry (SLDF). Subjects were subdivided into two groups based on glaucoma subty pe (normal-tension vs primary openangle glaucoma) and severity (mild vs moderat e-advanced). RESULTS: Twenty eyes of 20 patients with associated glaucomatous v isual field loss were enrolled. No significant differences in age, gender, intra ocular pressure, systemic comorbidity, number of antiglaucoma medications, and p rior filtration surgery were observed between the groups based on the type and s everity of glaucoma. The prevalence of clinically significant (>70%) carotid st enosis, mean peripapillary blood flow assessed by SLDF, mean erythrocyte sedimen tation rate, mean hematocrit, mean hemoglobin, and positive FTA-ABS was similar in both groups. Severity of glaucomatous damage as determined by visual field m ean defect did not correlate with the degree of carotid artery stenosis (R2< 0.0 001, P = 0.99) or peripapillary blood flow derived from mean SLDF (R2=0.000 5, P =0.92). CONCLUSION: Data from this pilot study demonstrate that the prevalence o f hemodynamically significant carotid stenosis, peripapillary blood flow, and se rologic abnormalities are similar in patients with normal-tension and primary o pen-angle glaucoma, and do not correlate with glaucoma severity.
出处
《世界核心医学期刊文摘（眼科学分册）》
2005年第2期46-46,共1页
Digest of the World Core Medical Journals:Ophthalmology
