摘要
目的:评价霉酚酸酯联合激素治疗难治性肾病综合征的疗效及安全性。方法:42例难治性肾病综合征患者,随机分为:观察组22例和对照组20例。观察组接受MMF治疗,对照组接受环磷酰胺(CTX)冲击治疗,观察治疗前后的相关临床指标变化并进行评价。结果:治疗24周后:MMF组总有效率为81.81%,与CTX组疗效无显著性差异(P】0.05);MMF组血清白蛋白、24h尿蛋白定量较前均有明显改善(P【0.05),总有效率两组相比无显著性差异(P】0.05)。结论:霉酚酸酯治疗难治性肾病综合征是安全、有效的。
Objective:To investigate the effect of mycophenolate mofeil and prednisolone in treatment of refractory nephropathy syndrome.Methods:42 nephropathy patients were divided into two groups random. The Observer group patients received mycophenolate mofeil and prednisolone,the control groups were treated with cyclophosphamide and prednisolone. A series of experimental datas were observed before the test and every two weeks in the test period.Results:After receiving mycophenolate mofeil, the proteinuria was deceased significantly in the test group (P<0.05),serum albumin were increased significantly(P<0.05),total efficiency rate was 81.8%,contracted with cyclophosphamide,the efficiency of mycophenolate mofeil on treating refractory neph-ropathy syndrome is no statistically different(P>0.05).Conclusion:Mycophenolate mofeil is an efficient and security agent on treating refractory nephropathy syndrome.
出处
《临床医药实践》
2009年第5Z期1725-1726,共2页
Proceeding of Clinical Medicine
关键词
霉酚酸酯
治疗
肾病综合征
Mycophenolate mofeil
Treatment
Nephropathy syndrome
