雷贝拉唑联合多潘立酮治疗反流性食管炎46例临床分析被引量：3

Rabeprazole and domperidone combined treatment of reflux esophagitis of 46 cases

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摘要目的:观察雷贝拉唑联合多潘立酮治疗反流性食管炎的临床疗效。方法:92例反流性食管炎患者随机分为2组各46例,治疗组予以雷贝拉唑联合多潘立酮治疗;对照组予以法莫替丁联合多潘立酮。评价2组治疗6 w时临床症状改善情况及治疗6 w后内镜下食管炎愈合情况。结果:2组药物治疗6 w后,症状缓解总有效率、胃镜下食管炎愈合总有效率及痊愈率治疗组均高于对照组(P<0.05,0.01)。结论:雷贝拉唑联合多潘立酮治疗反流性食管炎,症状改善及内镜下食管炎愈合情况疗效肯定。 Objective:Rabeprazole joint domperidone treatment of re?ux esophagitis(RE) therapy.Methods:92 patients with RE were randomly divided into 2 groups of 46 cases,the treatment group was combined rabeprazole domperidone treatment;control group were given famotidine domperidone.Evaluation of two group treatment for 6 weeks symptom improvement and endoscopic treatment for 6 weeks after healing of esophagitis.Results:2 groups after 6 weeks of drug treatment,the total effective symptom relief,endoscopic healing of esophagitis,the total effective rate and cure rate in treatment group were higher than the control group(P<0.05,0.01).Conclusion:Rabeprazole joint domperidone treatment of RE,symptom improvement and endoscopic healing of esophagitis positive effect.

作者唐纯

机构地区祁阳县人民医院消化内科

出处《临床医药实践》 2010年第8X期988-989,共2页 Proceeding of Clinical Medicine

关键词反流性食管炎雷贝拉唑法莫替丁多潘立酮 reflux esophagitis rabeprazole famotidine domperidone

分类号 R571 [医药卫生—消化系统]

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1王家,侯晓华,吴小平,凌奇荷,李继昌,罗和生.胃食管反流病与质子泵抑制剂[J].中华消化杂志,2003,23(3):176-177. 被引量：48
2许大波.酸相关疾病治疗研究进展[J].中国医药导刊,2003,5(2):101-103. 被引量：19

二级参考文献15

1[1]Lagergren J, Bergstrom R, Lindgren A, et al. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med, 1999; 340(11): 825～ 831
2[2]Fass R, Ofman JJ. Gastroesophageal reflux disease-should we adopt a new conceptual framework? Am J Gastroenterol, 2002;97(8): 1901 ～ 1909
3[3]Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med, 2002;347(15): 1175～ 1186
4[4]McColl KE, el - Nujumi AM, Chittajallu RS, et al. A study of the patho genesis of Helicobacter pylori negative chronic duodenal ulceration. Gut,1993;34(6): 762～768
5[5]el - Omar E, Penman I, Ardill JE, et al. A substantial proportion of non ulcer dyspepsia patients have the same abnormality of acid secretion as duodenal ulcer patients. Gut, 1995;36(4): 534 ～ 538
6[6]McColl K, Murray L, El - Omar E, et al. Symptomatic benefit from erad icating Helicobacter pylori infection in patients with nonulcer dyspepsia. N EnglJ Med, 1998;339(26): 1869～1874
7[7]BlumAL, Talley NJ, O' Morain C, etal. Lack of effect of treating Heli cobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus Clarithromycin and Amoxicillin Effect One Year after Treatment(OCAY) Study Group. N Engl J Med, 1998;339(26): 1875 ～ 1881
8[8]Zhang Q, Lehmann A, Rigda R, et al. Control of transient lower oesophageal sphincter relaxations and reflux by the GABA(B) agonist baclofen in patients with gastro - oesophageal reflux disease. Gut, 2002;50(1): 19 ～ 24
9[9]Spechler SJ, Lee E, Ahnen D, et al. Long -term outcome of medical and surgical therapies for gastroesophageal reflux disease: follow - up of a ran domized controlled trial. Jama, 2001;285(18): 2331 ～ 2338
10[10]Triadafilopoulos G, DiBaise JK, Nostrant TI, et al. The Stretta procedure for the treatment of GERD: 6 and 12 month follow - up of the U.S. open label trial. Gastrointest Endosc, 2002;55(2): 149 ～ 156