摘要
目的 探讨立体定向放射治疗 (SRT)肝癌的临床疗效。方法 采用立体定向伽玛射线体部治疗系统治疗 82例肝癌患者。根据肿瘤的位置、临床靶体积、病人的身体状况与治疗目的 ,制定放射治疗计划及调整剂量分布。等剂量曲线 5 0～ 90 %,周边照射剂量 2 5 0 0～ 480 0cGy ,中位剂量 32 86 2cGy ,分割处方剂量 30 0～ 80 0cGy ,重复治疗 4～ 12次 ,隔日治疗。结果 治疗结束后 3至 12个月 ,肝区疼痛症状缓解率为 91 7%,生存质量明显提高。 6 5例复查CT或MRI,肿瘤消失 10例 ( 15 4 %) ,缩小 33例 ( 5 0 8%) ,无变化 16例 ( 2 4 6 %) ,增大 6例 ( 9 2 %) ,有效率为 90 8%。无放射性肝炎等严重治疗反应发生。结论 SRT使肿瘤局部得到准确的高剂量照射 ,周围正常组织损伤较小 ,近期治疗效果较为理想 ,为肝癌患者提供了一种新的治疗方法。
Aim To investigate clinical therapeutic effectiveness of stereotactic radiotherapy(SRT) in 82 patients with hepatocarcinoma.Methods 82 patients were treated with stereotactic Gama Ray Body Therapeutic System.Radiotherapeutic plan was worked out and dosage distribution were set on the basis of the carcinoma position,clinical target volume,health condition of patients and therapeutic aim.The isodosage curve was 50～90%,and the fractional doses was 300～800 cGy.The therapy was repeated for 4～12 times,every two days one time.Results 3 to 12 months after the therapy,the remission rate of hepatic pain was 91.7%.The survival quality of patients was improved significantly.65 patients received CT or MRI test.The carcinoma disappeared in 10(15.4%) patients,shrank in 33(50.8%),unchanged in 16(24.6%),and augmented in 6 (9.2%).The efficient rate was 90.8%.There was no evidence to confirm any radiohepatitis and other serious side effect after therapy.Conclusions SRT can give accurate and high dose irradiation to carcinoma,and there is only mild damage to the surrounding tissues.The short term therapeutic effectiveness of hepatocarcinoma with stereotatic radiotherapy is satisfactory.
出处
《胃肠病学和肝病学杂志》
CAS
2002年第3期235-236,238,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
立体定向放射治疗
肝癌
临床研究
疗效
治疗
放射疗法
Stereotactic radiotherapy SRT Hepatocarcinoma Short term therapeutic effectiveness
