摘要
微量元素硒是机体正常生长的必需营养素,它能作为谷胱甘肽过氧化物酶组成部分,参与破坏机体代谢过程中产生的过氧化物,保障细胞膜或蛋白质中特定基团免受损害。随研究深入,发现体内硒水平与肿瘤发生率有密切关系。从实验动物获得的绝大多数资料支持硒是肿瘤细胞抑制剂的论点,特别是对上皮细胞。流行病学调查也提示硒缺乏与某些疾病产生有关。近年来报道用硒治疗消化道肿瘤,有一定成效。
The growth of SMMC-7721 human hepatocarcinoma cell line was inhibited remarked-ly in the presence of 2.5-10μmol/L sodium selenite. It was also found that the deposi-tion of fibronectin on cell surface and the secretion of fibronectin into culture mediumwere both increased by2. 5μmol/L selenite.This concentration of selenite also showed aninhibitory effect on the secretion of alpha fetoprotein which reached a maximum on the4th day of culture and was inhibited 31%as compared with the control cells.The selenitetreated cell showed a decrease of bisecting N-acetylglucosamine and core fucose in thecore structure of glycoprotein asparagine-linked oligosaccharides on the cell surface.All the above mentioned results suggested that selenite induces the synthesis of fibro-nectin and changes the structure of surface oligosaccharides that are related to therestoration of cell contact inhibition and the decrease of cell growth, and selenite caninduce the differentiation of hepatocarcinoma cell toward normality.
出处
《肿瘤》
CAS
CSCD
北大核心
1991年第3期133-136,共4页
Tumor
