摘要
目的 根据流体动力学平衡控释系统 (HBS)原理研制了盐酸昂丹司琼胃漂浮缓释片 ,并对其体外释放性能进行研究。方法 通过测定盐酸昂丹司琼释放度 ,进行释放机制及影响因素研究。用紫外分光光度法测定主药昂丹司琼的含量。结果 盐酸昂丹司琼胃漂浮缓释片体外释放曲线符合一级动力学方程和Higuchi方程。结论 该制剂有明显缓释作用 ,且制备工艺简单 。
OBJECTIVE: To develop the ondansetron hydrochloride floating tablets based on the hydrodynamically balanced drug delivery system(HBS), and evaluate its dissolution in vitro. METHODS: The release mechanism and the influence factors were studied by determining the dissolution. The content of ondansetron in the sustained release tablets was determined by UV spectrophotometry. RESULTS: The release profile of ondansetron hydrochloride from the tablets followed the first-order dynamics equation and Higuchi kinetics equation. CONCLUSION: The prepared sustained-release tablets showed a obviously sustained-release effect, and the preparation process was simple. It is worth further development and application in the clinic.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2002年第9期678-680,共3页
Chinese Pharmaceutical Journal
