摘要
目的 探讨定量测定胰腺癌患者血清12种肿瘤标志物的临床意义。方法 用蛋白芯片技术定量测定42例正常人、30例胰腺癌和16例胰腺炎患者血清12种肿瘤标志物的变化并对检测效果进行评价。结果 42例正常人血清CA19-9(KU/L)、NSE(μg/L)、CEA(μg/L)、CA242(KU/L)、Ferritin(μg/L)、β-HCG(μg/L)、AFP(μg/L)、f-PSA(μg/L)、PSA(μg/L)、CA125(KU/L)、HGH(μg/L)和CA153(KU/L)的含量分别为:12.42±10.62、2.24±1.41、1.78±1.04、5.73±5.67、91.17±78.47、0.64±0.33、2.96±3.89、0.13±0.11、0.62±1.38、5.46±9.53、1.63±2.37、9.83±9.40;30例胰腺癌患者血清12种肿瘤标志物含量依次为:279.47±402.0、9.50±11.30、8.57±21.95、98.23±89.33、301.98±216.63、1.49±2.28、5.50±7.69、0.27±0.62、1,62±3.23、167.16±252.49、3.38±8.38、43.22±99.34;16例胰腺炎患者其含量依次为:53.38±86.38、12.78±28.50、1.20±0.94、22.99±51.13、343.43±308.27、3.63±11.99、5.09±3.66、0.10±1.32、0.66±0.61、98.67±212.23、1.79±1.63、4.15±2.13。该蛋白芯片测定的敏感性为70.0％,特异性为89.7％,阳性预测值为77.8％,阴性预测值为88.1％。结论 采用蛋白芯片技术同时测定患者血清中多种肿?
Objective To study the clinical significance of serum 12 tumor markers levels in patients with pancreatic cancer. Methods The values of serum 12 tumor markers were detected by a proteinchip in 42 controls, 30 pancreatic cancers and 16 pancreatitis. The clinical effect of using the proteinchip was evaluated. Results Serum levels of CA19-9(KU/L), NSE(μg/L), CEA(μg/L), CA242(KU/L), Ferritin (μg/L) , β-HCG (μg/L), AFP(μg/L), f-PSA(μg/L), PSA(μ g/L), CA125 ( KU/L), HGH(g/L)and CA153(KU/L) were 12. 42 ± 10. 62, 2. 24±1. 41, 1. 78 ± 1. 04, 5. 73 ± 5.67, 91.17 ± 78.47, 0.64 ±0.33,2.96±3.89,0.13±0.11,0.62±1.38,5.46±9. 53, 1.63 ± 2.37 and 9. 83 ± 9. 40 in controls, 279. 47 ± 402. 0, 9. 50±11. 30, 8. 57 ± 21. 95, 98. 23 ± 89. 33, 301. 98 ± 216. 63, 1. 49 ± 2. 28, 5. 50 ± 7. 69, 0. 27 ± 0. 62, 1. 62 ± 3. 23, 167. 16 ± 252. 49, 3. 38 ± 8. 38 and 43. 22±99. 34 in 30 pancreatic cancer, 53. 38 ± 86. 38, 12. 78 ± 28. 50, 1. 20 ± 0. 94, 22. 99 ± 51. 13, 343.43 ± 308.27, 3.63 ± 11.99, 5.09 ± 3.66, 0.10 ± 1.32, 0.66 ± 0.61, 98.67 ± 212.23, 1.79 ± 1.63 and 4. 15 ± 2. 13 in 16 pancreatitis, respectively. The sensitivity and specificity, positive and negative predictive values of the proteinchip determination were 70. 0%, 89. 7%, 77. 8% and 88. 1%, respectively. Conclusions Multi-tumor markers levels in serum can be detected by using proteinchip. The proteinchip was proved to be useful in survey and observation of curative effect for patients with carcinoma.
出处
《胰腺病学》
2002年第3期151-154,共4页
Chinese JOurnal of Pancreatology
