摘要
目的观察IL-17和STAT3在结直肠癌组织中的表达,探讨其与直肠癌的血管生成和肿瘤发展的关系。方法采用免疫组织化学S-P法检测2013年5月至2016年5月期间我院的80例结直肠癌组织和80例正常组织中的IL-17和STAT3蛋白的表达情况。结果 IL-17在肿瘤细胞及肠黏膜固有层淋巴细胞胞浆中的阳性表达率为80.0%(64/80),正常组织中的阳性表达率10%(8/80),组间比较具有统计学意义(P<0.05);IL-17与Duke's分期和肿瘤的分化程度有关,有统计学意义(P<0.05)。STAT3在肿瘤胞浆中的阳性表达率为90.0%(72/80),正常组织中的表达率为2.7%(2/80),组间比较具有统计学意义(P<0.05);STAT3表达与淋巴转移、细胞分化程度及Duke's分期有关,有统计学意义(P<0.05)。结论 IL-17和STAT3在结直肠癌组织中高表达,与肿瘤的发生、发展和血管生成密不可分,是监测结直肠癌进展的重要指标。
Objective To investigate the expression of IL-17 and STAT3 in colorectal cancer,and to explore its relationship with angiogenesis and tumor development of colorectal cancer.The expression of 80 cases of colorectal cancer tissues during May 2016 in our hospital and 80 cases of normal tissue IL-17 and STAT3 protein-were detected in May 2013 by immunohistochemical S-P method.Results IL-17 expression in tumor cells and intestinal lamina propria lymphocyte cytoplasm was 80.0%(64/80),normal tissue expression rate of 10%(8/80),with a statistical comparison between groups significance(P <0.05)) IL-17 and Duke's stage and differentiation degree of tumor related,statistically significant(P <0.05).STAT3 in the cytoplasm of tumor expression was 90.0%(72/80) and normal tissues was 2.7'%(2/80) compared with statistical significance(P <0.05) between the two groups;STAT3 expression lymph node metastasis,cell differentiation,and Duke's staging,with statistical significance(P <0.05).Conclusion IL-17 and STAT3 was highly expressed in colorectal cancer tissues,generating inseparable tumors,and vascular development,monitor progress of colorectal cancer is an important indicator.
出处
《结直肠肛门外科》
2016年第S2期146-147,共2页
Journal of Colorectal & Anal Surgery
