摘要
目的分析青海地区抗结核药物所致肝损伤的发生率和易感因素。方法选取本院收治的1 197例初治肺结核患者作为研究对象,统计患者肝功能损伤发生率,分析不同民族、不同年龄、不同性别及化疗药物的影响。结果发生肝功能损伤52例,总发生率为4.43%;不同民族肝功能损伤发生率分别为:汉族1.17%,藏族2.25%,回族0.75%,其他民族0.17%。汉族与藏族比较差异有统计学意义(P<0.05),回族与藏族比较差异有统计学意义(P<0.05);不同年龄肝功能损伤发生率分别为:≥60岁3.76%,<60岁0.58%。组间比较差异有统计学意义(P<0.05);不同性别肝功能损伤发生率分别为:男性2.17%,女性2.17%。两组患者男女比例比较差异无统计学意义(P>0.05);化疗药物导致的肝功能损伤发生率分别为:异烟肼0.17%、利福平1.59%、吡嗪酰胺2.18%。结论高原地区抗结核药物所致的肝损伤发生率为4.43%,藏族发生率最高、年龄≥60岁发生率较高,化疗药物中吡嗪酰胺发生率最高。
Objective To investigate the incidence and risk factors of liver injury caused by anti tuberculosis drugs in Qinghai area. Methods A total of 1 197 cases of primary pulmonary tuberculosis treated in our hospital were selected as the subjects.The incidence of liver function injury was analyzed,and the effects of different nationalities,different ages,different sex and chemotherapeutic drugs were analyzed. Results There were 52 cases of liver function injury,the total incidence rate was 4.43%,and the incidence of liver function injury in different nationalities was 1.17%,2.25%,0.75% and 0.17% of the other ethnic groups.There was a significant difference between the Han and the Tibetans(P<0.05),as well as between the Hui and the Tibetans(P<0.05). The incidence of liver function injury at different ages were:3.76% in those ≥ 60 years,0.58% in those<60 years,and the difference between groups was statistically significant(P<0.05);the incidence of liver dysfunction in different genders was 2.17% and 2.17% respectively,without significant difference(P>0.05). The incidence of liver function injury caused by chemotherapeutic drugs was isoniazid 0.17%,rifampicin 1.59%,and 2.18% of pyrazinamide. Conclusion The incidence of liver injury caused by anti-tuberculosis drugs was 4.43% in high altitude area,among which Tibetans had the highest incidence,age ≥ 60 years old had the highest incidence,and the incidence of pyrazinamide among chemotherapy drugs was the highest.
作者
丁月荷
雷琼
李秀萍
DING Yuehe;LEI Qiong;LI Xiuping(Qinghai Fourth People's Hospital,Xining,Qinghai 810000,China)
出处
《大医生》
2018年第7期164-165,共2页
Doctor
关键词
抗结核药物
肝损伤
不同民族
化疗
anti tuberculosis drugs
liver injury
different ethnicity
chemotherapy
