摘要
雷公藤微囊（５～１５ｍｇ·ｋｇ－１）对大鼠角叉菜胶足肿胀、棉球肉牙肿及大鼠佐剂性关节炎（ＡＡ）均有明显的抑制作用，并能抑制ＡＡ大鼠腹腔巨噬细胞产生的白细胞介素１（ＩＬ－１）和小鼠溶血素抗体生成。体外实验发现，雷公藤微囊对刀豆蛋白诱导的小鼠脾细胞增殖反应及脂多糖诱导的大鼠腹腔巨噬细胞产生的ＩＬ－１均具有剂量依赖性的抑制作用。提示雷公藤微囊不仅具有明显的抗炎作用，而且具有免疫抑制作用。
The pharmacodynamics of the microcapsul of Tripterygium Wilfordii Hook(TC) were studied. Our results showed that TC( 5￣15 mg·kg-1) had markedly inhibitory effect on carrageenan eddema,cotton Pettet granulomatosis and polyarthritis symptoms of adjuvant arthritis (AA) in rats. It was also showed that TC could inhibit elevated IL-1 released from peritoneal macrophages (PMΦ) of AA in rats and diminished hemolysin responses in mice. In vitro, TC could not only inhibit ConA-induced proliferative reaction of splenocytes in mice, but also suppress the release of IL-1 from PMΦ in normal rats with dose-dependent manner. These results suggest that TC might have antiinflammatory and immunosuppressic effects.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1994年第5期345-348,共4页
Chinese Pharmacological Bulletin
关键词
雷公藤
微囊
抗炎
免疫抑制
tripterygium wilfordii hook
microcapsul
antiinflammation
immunosuppression
