摘要
用二丁基氧化锡与 2 吡啶甲酸反应 ,合成了二 {氧合 -二 [2 吡啶甲酸二丁基锡 (IV) ] },并进行了元素分析、红外光谱、核磁共振锡谱表征 .X射线单晶衍射分析表明 ,化合物是以Sn2 O2 四面体为中心的 ,中心对称的二聚体结构 ,内环锡为五配位的畸变三角双锥构型 ,外环锡为六配位的畸变八面体结构 .生物活性测试结果表明 ,该配合物具有较强的体外抗癌活性 .
Bis{oxo bis[(2 pyri^di^ne^car^boxy^lato)dibutyltin(IV)]} was synthesized by the reaction of 2 py^ridi^ne^car^boxy^lic acid with dibutyltin(IV) oxide. The compound was tested against two human tumour cell lines: MCF 7 and WiDr. The results showed that this compound had higher activities in vitro . The compound has been characterized by elemental analysis, IR and 119 Sn NMR and determined by X ray single crystal diffraction. The compound is in centrosymmetric dimer structure mode with a four member central endo cyclic Sn 2O 2 unit in which the bridging oxygen atoms are tri coordinated. Each bridging oxygen atom also connects with an exo cyclic tin atom. The endo cyclic tin atoms are five coordinated with geometry of distorted trigonal bipyramid, while the exo cyclic tin atoms are six coordinated with geometry of distorted octahedron.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2004年第4期433-437,353,共6页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金 (No.2 0 2 71 0 2 5)
教育部骨干教师基金
山东省自然科学基金 (No.Y2 0 0 1B0 2 )资助项目
关键词
有机锡
2-吡啶甲酸
合成
晶体结构
organotin, 2 pyridinecarboxylic acid, synthesis, crystal structure.
