摘要
目的研究CD44分子与肿瘤浸润转移的关系。方法免疫组织化学方法。结果广谱型CD44、CD44v6在正常喉、下咽上皮组织及喉鳞状细胞癌(LSCC)、下咽鳞状细胞癌(HSCC)中均有不同程度表达,主要染色在细胞膜,广谱型CD44、CD44v6在LSCC、HSCC中表达率与癌组织分化程度呈负相关(P<0.05,P<0.05);广谱型CD44与转移潜能是负相关(P<0.01)。CD44v3在正常组织及癌组织中均未见表达。结论广谱型CD44分子可能作为LSCC、HSCC提示转移和预后的指标之一。
PURPOSE To study the relationship between expression of adhesion molecules CD44 and the metastatic potential of the squamous cell carcinoma in larynx and hy-popharynx.METHODS Using immunohischemistry techniques.RESULTS Staining along cell membranes of tumor cells is well observed in sections that have been stained with antibodies to CD44,CD44v6.Increased expression of CD44 and CD44v6 is correlated with a decreased differentiation(P<0.05,P<0.05),and decreased expression of CD44 is correlated with an increase in metastasis(P<0.01).TTiere is no expression in sections stained with CD44v3 antibody.CONCLUSIONS The loss of cell adhesion im-pljed by decreased expression of CD44 may be one of the determinants of metastasis and prognosis in patients with LSCC and HSCC.
出处
《中国眼耳鼻喉科杂志》
1999年第3期81-84,151,共5页
Chinese Journal of Ophthalmology and Otorhinolaryngology
关键词
CD44
喉癌
下咽癌
转移
CD44
laryngeal carcinoma
hypo-pharyngeal carcinoma
metastatic.
