摘要
目的:观察放射治疗并同期化疗Ⅲb期宫颈癌的疗效及不良反应。方法:对59例Ⅲb期宫颈癌患者随机分为放射治疗+化疗组(放、化组)和单纯放射治疗组(单放组)。两组放疗方案相同,化疗与放疗同时进行。结果:近期有效率放、化组为100%,单放组为92.3%,两组无明显差异(P>0.05);5年生存率放、化组为69.7%,单放组为42.3%,两组有显著差异(P<0.05);恶心、呕吐消化道反应和白细胞降低率放、化组较单放组明显高(P<0.01P<0.05),放射性直肠炎、膀胱炎两组无差异(P>0.05);远处转移率单放组明显高(P<0.05)。结论:放射治疗同时化疗可提高局部控制率及5年生存率,减少远处转移率。不良反应经对症治疗后,症状减轻或消失。
Objective: To analyze the curative effect and the side effect of the Ⅲb uterocervical cancer with radiotherapy and chemotherapy. Methods: Fifty-nine cases with Ⅲb uterocervical cancer were randomly divided into two groups, the group one with radiotherapy and chemotherapy, and the group two with radiotherapy simplicity. The twogroups have the same radiotherapy. At the same time, give chemotherapy to the group one, adopting the PVB project. Results: Recent efficient rate in group one was 100% and 92.3% in group two, but there is no significant difference between group one and group two (P>0.05). Survival rate within 5 years was 69.7% in group one and was 42.3% in group two, there is significant difference between the group one and the group two (P<0.05). nausea, vomit and decreased leukocyte is significant higher in group one than in group two (P<0.01, P<0.05). There is no significant difference in group one and group two in radioactive rectitis and cystitis(P>0.05). Distant metastasis rate in group group two is significant higher than in group one. Conclusions: Radiotherapy and chemotherapy given at the same time can increase the local control rate, survival rate within 5 years and decrease the distant metastasis rate with increasing side effect.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2004年第18期26-28,共3页
Chinese Journal of Clinical Oncology
关键词
宫颈癌
放射治疗
化学疗法
预后
Uterocervical cancer Radiotherapy chemotherapy Prognosis
